{"id":"W4386945518","doi":"10.1038/s41467-023-41603-0","title":"C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Clarendon Fund; St. John's College, University of Oxford; Medical Research Council; Oxford Martin School, University of Oxford; Natural Sciences and Engineering Research Council of Canada; Dementias Platform UK; UK Dementia Research Institute; Chinese Academy of Medical Sciences; China Scholarship Council; Lunds Universitet; University of Oxford; Motor Neurone Disease Association; Parkinson's UK; Department of Health and Social Care; National Institute for Health and Care Research; Wellcome Trust; Alzheimer's Society; Stem Cell Network; Memorial Sloan-Kettering Cancer Center; Government of Canada; Academy of Medical Sciences; Wellcome","keywords":"C9orf72; Microglia; Amyotrophic lateral sclerosis; Biology; MMP9; Neuroinflammation; Cell biology; Neuroscience; Immunology; Inflammation; Medicine; Downregulation and upregulation; Pathology; Trinucleotide repeat expansion; Gene; Genetics; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003274455,0.0002116736,0.0003157583,0.0002629707,0.0006116263,0.00007475883,0.0008504826,0.0003821921,0.00009143768],"category_scores_gemma":[0.0003545005,0.0001799192,0.00009497414,0.0006882797,0.0002532155,0.0001082634,0.0007154796,0.001527466,0.0005425828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001386228,"about_ca_system_score_gemma":0.00007115365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002785625,"about_ca_topic_score_gemma":0.0002902528,"domain_scores_codex":[0.9982725,0.0002140296,0.0003227876,0.0003623528,0.0004058448,0.0004224878],"domain_scores_gemma":[0.9969095,0.0001703438,0.00009448812,0.002159756,0.0002902171,0.0003756785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00006835995,0.0002049199,0.03175272,0.0001005113,0.0001082989,0.00003044632,0.0009302647,0.000002290591,0.8723367,0.0009362819,0.09215309,0.001376038],"study_design_scores_gemma":[0.0007511622,0.0001596915,0.8626933,0.0001575013,0.00004888407,0.00002778713,0.0001348482,0.0002182805,0.002114363,0.0001155499,0.1333519,0.0002267463],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.944778,0.001661902,0.000005794574,0.04913275,0.00009133263,0.001824194,0.0001025134,0.0003792215,0.002024249],"genre_scores_gemma":[0.9903349,0.000547525,0.001176786,0.001659663,0.0001314724,0.00024071,0.0002152057,0.00005438992,0.005639306],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8702224,"threshold_uncertainty_score":0.7336892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04985378484391397,"score_gpt":0.3764209137492672,"score_spread":0.3265671289053532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}