{"id":"W4386945518","doi":"10.1038/s41467-023-41603-0","title":"C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Clarendon Fund; St. John's College, University of Oxford; Medical Research Council; Oxford Martin School, University of Oxford; Natural Sciences and Engineering Research Council of Canada; Dementias Platform UK; UK Dementia Research Institute; Chinese Academy of Medical Sciences; China Scholarship Council; Lunds Universitet; University of Oxford; Motor Neurone Disease Association; Parkinson's UK; Department of Health and Social Care; National Institute for Health and Care Research; Wellcome Trust; Alzheimer's Society; Stem Cell Network; Memorial Sloan-Kettering Cancer Center; Government of Canada; Academy of Medical Sciences; Wellcome","keywords":"C9orf72; Microglia; Amyotrophic lateral sclerosis; Biology; MMP9; Neuroinflammation; Cell biology; Neuroscience; Immunology; Inflammation; Medicine; Downregulation and upregulation; Pathology; Trinucleotide repeat expansion; Gene; Genetics; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002678049,0.0005007741,0.0003563128,0.0002058435,0.0002395162,0.0002931341,0.0001876025,0.0004362325,0.002014015],"category_scores_gemma":[0.0001353444,0.0001059314,0.0003481695,0.0001486561,0.0002355287,0.0001594112,0.0002024423,0.0007074576,0.0008113462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001581687,"about_ca_system_score_gemma":0.0001583364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000352181,"about_ca_topic_score_gemma":0.0005454022,"domain_scores_codex":[0.9996195,0.00004249034,0.00005310872,0.0000792526,0.0001358579,0.00006978121],"domain_scores_gemma":[0.9999001,0.00002016282,0.00002349832,0.00002031867,0.00001852895,0.00001744819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001183619,0.00003727303,0.0001242472,0.00004327588,0.00000752141,0.00013545,0.00001864591,0.00006939969,0.9983004,0.00004570717,0.00009280747,0.001006833],"study_design_scores_gemma":[0.00001967113,0.0002477531,0.003027035,0.00001335296,0.00002707707,0.0004245513,0.0000348307,0.0006936667,0.9927893,0.00005498862,0.002663201,0.000004641654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829002,0.00128405,0.007533371,0.0002023166,0.0001995665,0.0001394825,0.003364605,0.0002014181,0.004175063],"genre_scores_gemma":[0.9818794,0.001176339,0.006687003,0.0001900714,0.00004238071,0.0003286019,0.003602642,0.00005385701,0.006039729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002014015,"threshold_uncertainty_score":0.00673753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04985378484391397,"score_gpt":0.3764209137492672,"score_spread":0.3265671289053532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}