{"id":"W4386945701","doi":"10.1021/acs.analchem.3c02412","title":"Compendium of Chromatographic Behavior of Post-translationally and Chemically Modified Peptides in Bottom-Up Proteomic Experiments","year":2023,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Advanced Proteomics Techniques and Applications","field":"Chemistry","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Chemistry; Peptide; Formic acid; Moiety; Chromatography; Amino acid; Chemical modification; Residue (chemistry); Combinatorial chemistry; Stereochemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001640802,0.0008831906,0.0006366604,0.001248963,0.0003659124,0.001050701,0.0004393227,0.0003966241,0.000819326],"category_scores_gemma":[0.002790054,0.0002981767,0.0005040833,0.001117478,0.0004474984,0.0006006014,0.0005654392,0.0008409771,0.0005729642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003711876,"about_ca_system_score_gemma":0.0004724111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000774634,"about_ca_topic_score_gemma":0.00148837,"domain_scores_codex":[0.998757,0.0001082126,0.000101091,0.0002509529,0.0007119767,0.00007076035],"domain_scores_gemma":[0.9980367,0.0006947847,0.0003061287,0.0004004027,0.0004727607,0.00008924917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008927722,0.00002907066,0.001566714,0.0001428514,0.00004628272,0.00007937133,0.00005439999,0.0003978774,0.9822257,0.00009362098,0.0001574215,0.01511761],"study_design_scores_gemma":[0.000006099675,0.0001807273,0.02059769,0.00002254274,0.00009720718,0.0005371112,0.00004327482,0.004952085,0.9688689,0.0002145175,0.004428389,0.00005149476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7957678,0.00458077,0.1842366,0.000214987,0.000137971,0.0003048206,0.008299981,0.002087557,0.004369617],"genre_scores_gemma":[0.6407683,0.005651965,0.333309,0.0003916155,0.0000985431,0.0006302685,0.01528759,0.0008177917,0.003044826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001640802,"threshold_uncertainty_score":0.008677483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.019339517672246,"score_gpt":0.3004987851345075,"score_spread":0.2811592674622614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}