{"id":"W4386946603","doi":"10.1021/acsomega.3c04301","title":"Synthesis and Cytotoxicity of Monomethylated Betulinic Acid 3-O-α-l-Rhamnopyranosides","year":2023,"lang":"en","type":"article","venue":"ACS Omega","topic":"Natural product bioactivities and synthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Chicoutimi","funders":"Institute of Cancer Research","keywords":"Betulinic acid; Cytotoxicity; Chemistry; Residue (chemistry); Monosaccharide; In vitro; Biochemistry; Stereochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003547812,0.0001893532,0.000291014,0.0001123988,0.00009349228,0.00002300785,0.0002069565,0.0002145974,0.000003221908],"category_scores_gemma":[0.001330835,0.0001705235,0.0001059063,0.0003085017,0.0001792564,0.000010492,0.0001980318,0.0001066993,0.00001479066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007548271,"about_ca_system_score_gemma":0.00003293779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002945345,"about_ca_topic_score_gemma":0.000007656608,"domain_scores_codex":[0.9988007,0.00007877799,0.0002593409,0.0004134945,0.0001408501,0.0003068413],"domain_scores_gemma":[0.9990696,0.0002575328,0.0001241041,0.0003998994,0.00006397953,0.00008485802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002549519,0.00003093125,0.002208204,0.00004794602,0.0001199057,0.000002772856,0.00006881192,0.000004775884,0.9905724,0.00002362033,0.00221789,0.004677267],"study_design_scores_gemma":[0.0001552966,0.0001203492,0.008733358,0.00001674965,0.00003596924,0.000004998853,0.0002462682,0.00001518047,0.9852805,0.0002090603,0.005088442,0.00009381573],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966508,0.00205852,0.00001376403,0.0002306104,0.000100649,0.0001548618,0.0000878514,0.00004232306,0.0006606509],"genre_scores_gemma":[0.9967878,0.001850735,0.0001849275,0.00008531884,0.0001335758,0.00002595522,0.00003824937,0.0000291746,0.0008642924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006525155,"threshold_uncertainty_score":0.6953745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0141289860186983,"score_gpt":0.2401221198487445,"score_spread":0.2259931338300462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}