{"id":"W4386947067","doi":"10.1016/j.ijfoodmicro.2023.110414","title":"Dairy phages escape CRISPR defence of Streptococcus thermophilus via the anti-CRISPR AcrIIA3","year":2023,"lang":"en","type":"article","venue":"International Journal of Food Microbiology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre hospitalier de l'Université Laval; Centre hospitalier universitaire de Québec; Université Laval","funders":"National Institutes of Health; Ian's Friends Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Streptococcus thermophilus; CRISPR; Virulence; Biology; Bacteria; Microbiology; Genetics; Gene; Lactobacillus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001994574,0.0003547394,0.0002846935,0.0001826489,0.0001747828,0.0005578171,0.0002242117,0.0003941739,0.002010444],"category_scores_gemma":[0.0002977676,0.0001512111,0.0002757462,0.000119984,0.0002429197,0.0001556709,0.0005928789,0.0006756446,0.0008143574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002457124,"about_ca_system_score_gemma":0.0002404023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008682329,"about_ca_topic_score_gemma":0.0008556875,"domain_scores_codex":[0.9996327,0.00005198766,0.00002163949,0.00005347311,0.0001395432,0.0001006108],"domain_scores_gemma":[0.99985,0.00002679009,0.00004514587,0.00002120302,0.00003024102,0.00002655842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004522446,0.0000107596,0.0002956028,0.00001547054,0.000003091907,0.00002818092,0.00001527151,0.00004047485,0.9985338,0.00008294232,0.00003783607,0.0008913577],"study_design_scores_gemma":[0.00001021372,0.0002244418,0.007511951,0.000007765541,0.00001304288,0.0003754713,0.0001186337,0.001996031,0.9868546,0.0001039036,0.002772922,0.00001113638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993943,0.0003305991,0.003094198,0.0001281676,0.00003108899,0.00001426547,0.00011887,0.0001428063,0.002197026],"genre_scores_gemma":[0.9951103,0.00009060391,0.0009976154,0.00007849045,0.000003580659,0.000007490586,0.000132251,0.00002664855,0.003552925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002010444,"threshold_uncertainty_score":0.00672555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008794769853939134,"score_gpt":0.2990231007560469,"score_spread":0.2902283309021078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}