{"id":"W4386948541","doi":"10.1016/j.ygyno.2023.06.512","title":"ADAGIO: A phase IIb, open-label, single-arm, multicenter study assessing the efficacy and safety of adavosertib (AZD1775) as treatment for recurrent or persistent uterine serous carcinoma (039)","year":2023,"lang":"en","type":"article","venue":"Gynecologic Oncology","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Medicine; Serous fluid; Internal medicine; Oncology; Chemotherapy; Phases of clinical research; Carcinoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001217768,0.001319493,0.001926945,0.0005231932,0.0003830429,0.001291989,0.0008230014,0.001367308,0.003474347],"category_scores_gemma":[0.0006563366,0.000465861,0.001478392,0.0003998804,0.0008834671,0.0006124781,0.0002972894,0.003074931,0.0009953798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000656774,"about_ca_system_score_gemma":0.00152159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009099989,"about_ca_topic_score_gemma":0.002869754,"domain_scores_codex":[0.9997347,0.0001153392,0.00001213542,0.00004551167,0.00002829406,0.00006408701],"domain_scores_gemma":[0.9996735,0.00005277059,0.00006573666,0.00002493802,0.00001986002,0.0001631549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8144766,0.02691557,0.003522878,0.001956797,0.002598742,0.0001893232,0.0001884516,0.001687479,0.03587725,0.0006757604,0.008034559,0.1038767],"study_design_scores_gemma":[0.8611056,0.1247782,0.004583951,0.00005553541,0.000727922,0.0001816005,0.00005478339,0.0009025753,0.002514297,0.0002277501,0.004832601,0.00003524632],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9734081,0.01174262,0.001417356,0.001081171,0.0006764507,0.003088777,0.003537554,0.0004760016,0.004572032],"genre_scores_gemma":[0.9736909,0.006198568,0.003639641,0.002887437,0.0004062381,0.002799615,0.004692842,0.00007576742,0.005608838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003474347,"threshold_uncertainty_score":0.01162285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1887242369883604,"score_gpt":0.4593825056349651,"score_spread":0.2706582686466047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}