{"id":"W4386948731","doi":"10.1016/j.biopha.2023.115559","title":"DNA methylation-based depiction of the immune microenvironment and immune-associated long non-coding RNAs in oral cavity squamous cell carcinomas","year":2023,"lang":"en","type":"article","venue":"Biomedicine & Pharmacotherapy","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Division of Graduate Education; Fundação de Amparo à Pesquisa do Estado de São Paulo; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Region Syddanmark","keywords":"Immune system; Biology; DNA methylation; Cancer research; Tumor microenvironment; Cytotoxic T cell; Epigenetics; Immunotherapy; Immunology; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001887915,0.0001414719,0.0002007098,0.0007198516,0.00009655389,0.0002054564,0.0001437207,0.0001635126,0.0007670844],"category_scores_gemma":[0.0002309698,0.0001212376,0.0002105299,0.0004488035,0.00008235371,0.0001081721,0.0001906951,0.0001377477,0.0001463551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001882451,"about_ca_system_score_gemma":0.0001476305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004034771,"about_ca_topic_score_gemma":0.006069672,"domain_scores_codex":[0.9999424,0.000007238819,0.000003392174,0.00002483533,0.00001223873,0.000009897766],"domain_scores_gemma":[0.9999573,0.00001444912,0.000009843298,0.000004396564,0.000008652574,0.00000525558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008934322,0.0000327891,0.08416907,0.0002785344,0.0002003673,0.0001624812,0.0003516449,0.009909809,0.8467895,0.0003942827,0.0004611822,0.05635694],"study_design_scores_gemma":[0.00003862452,0.0002075577,0.6898067,0.00004219511,0.0003806349,0.0006301606,0.0003904243,0.1008575,0.2011519,0.001161539,0.005272551,0.00006029351],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869384,0.001347681,0.008458403,0.00003747288,0.000005082558,0.00001301685,0.002113464,0.0001590664,0.0009274411],"genre_scores_gemma":[0.9900178,0.0004658833,0.006878963,0.00002228845,0.000004425051,0.00002668645,0.001921888,0.00002648569,0.0006356103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004034771,"threshold_uncertainty_score":0.008022547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01180743565467521,"score_gpt":0.2848145041044972,"score_spread":0.2730070684498219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}