{"id":"W4386949028","doi":"10.1093/neuonc/noad125","title":"Optimizing preclinical pediatric low-grade glioma models for meaningful clinical translation","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"National Institute of Neurological Disorders and Stroke; Pediatric Brain Tumor Foundation; School of Medicine, Emory University; Array BioPharma; University of California, Los Angeles; Universitätsklinikum Heidelberg; Perelman School of Medicine, University of Pennsylvania; U.S. Department of Defense; Ian's Friends Foundation; Springworks Therapeutics; Deutsches Krebsforschungszentrum; National Cancer Institute; Alexion Pharmaceuticals; University of Toronto; Emory University; Deutschen Konsortium für Translationale Krebsforschung; Children's National Hospital; University of Pennsylvania; Hospital for Sick Children; Pfizer; Exelixis; Children's Hospital of Philadelphia; AstraZeneca; Brain Tumour Charity","keywords":"Medicine; MAPK/ERK pathway; Glioma; Microglia; Central nervous system; Stromal cell; Oncology; Brain tumor; Bioinformatics; Cancer research; Neuroscience; Internal medicine; Pathology; Signal transduction; Psychology; Biology; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007669615,0.0002154331,0.0007061657,0.0002877344,0.0001107176,0.00001671557,0.0001219587,0.000411462,0.00003048673],"category_scores_gemma":[0.00059924,0.000188651,0.000449699,0.0005196861,0.00007009588,0.00009485109,0.00004826434,0.0003359739,0.0001049434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008330228,"about_ca_system_score_gemma":0.0002499343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004149336,"about_ca_topic_score_gemma":0.000009606861,"domain_scores_codex":[0.9975355,0.0002264539,0.0008758528,0.0006352967,0.0002476063,0.0004792378],"domain_scores_gemma":[0.9950006,0.004077085,0.0001981202,0.0003255619,0.0001096316,0.0002889828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.008848934,0.02158963,0.1387123,0.001164243,0.001475682,0.008144844,0.004804363,0.02682043,0.1101624,0.004459252,0.1061109,0.567707],"study_design_scores_gemma":[0.09935198,0.03381456,0.03153541,0.0001760278,0.006347982,0.0007866006,0.0004716035,0.6469707,0.01958126,0.007980188,0.1514348,0.001548874],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837456,0.0004048458,0.001368987,0.01010172,0.001488433,0.001565394,0.00002767739,0.0003700203,0.0009273081],"genre_scores_gemma":[0.98977,0.0008084071,0.006429779,0.001081262,0.001315995,0.0004038906,0.0001103404,0.00006694465,0.00001340647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6201503,"threshold_uncertainty_score":0.7692963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1498459295181951,"score_gpt":0.4152956796911838,"score_spread":0.2654497501729887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}