{"id":"W4386949028","doi":"10.1093/neuonc/noad125","title":"Optimizing preclinical pediatric low-grade glioma models for meaningful clinical translation","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"National Institute of Neurological Disorders and Stroke; Pediatric Brain Tumor Foundation; School of Medicine, Emory University; Array BioPharma; University of California, Los Angeles; Universitätsklinikum Heidelberg; Perelman School of Medicine, University of Pennsylvania; U.S. Department of Defense; Ian's Friends Foundation; Springworks Therapeutics; Deutsches Krebsforschungszentrum; National Cancer Institute; Alexion Pharmaceuticals; University of Toronto; Emory University; Deutschen Konsortium für Translationale Krebsforschung; Children's National Hospital; University of Pennsylvania; Hospital for Sick Children; Pfizer; Exelixis; Children's Hospital of Philadelphia; AstraZeneca; Brain Tumour Charity","keywords":"Medicine; MAPK/ERK pathway; Glioma; Microglia; Central nervous system; Stromal cell; Oncology; Brain tumor; Bioinformatics; Cancer research; Neuroscience; Internal medicine; Pathology; Signal transduction; Psychology; Biology; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001620013,0.001026645,0.0006723823,0.0006470272,0.0002650776,0.001327484,0.001167083,0.001070504,0.003774085],"category_scores_gemma":[0.00156714,0.0003762202,0.0007118515,0.0003748601,0.0004353288,0.001024004,0.0007097986,0.002434519,0.001259511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000868738,"about_ca_system_score_gemma":0.001403223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001756151,"about_ca_topic_score_gemma":0.002385739,"domain_scores_codex":[0.999562,0.0001330427,0.00002784639,0.00006492089,0.0001459932,0.00006618208],"domain_scores_gemma":[0.9994385,0.0001666553,0.00009653982,0.00006685855,0.000133646,0.00009784739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001878742,0.002483954,0.004546796,0.004703312,0.0003886621,0.00135471,0.0004210272,0.04913936,0.7299668,0.02107007,0.03289257,0.151154],"study_design_scores_gemma":[0.0006160675,0.01141882,0.003934904,0.0009694354,0.0009821218,0.002164893,0.0003941664,0.06045477,0.6154722,0.0120974,0.2913423,0.0001527777],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.371,0.06882486,0.4872113,0.007789792,0.00301852,0.004380669,0.01559832,0.003977504,0.038199],"genre_scores_gemma":[0.742712,0.06932841,0.1561371,0.002180133,0.0003301167,0.004551333,0.01383253,0.0008598482,0.01006838],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003774085,"threshold_uncertainty_score":0.01262552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1498459295181951,"score_gpt":0.4152956796911838,"score_spread":0.2654497501729887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}