{"id":"W4386950405","doi":"10.1021/acs.jmedchem.3c01151","title":"Rearmed Bifunctional Chelating Ligand for <sup>225</sup>Ac/<sup>155</sup>Tb Precision-Guided Theranostic Radiopharmaceuticals─H<sub>4</sub>noneunpaX","year":2023,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of British Columbia; TRIUMF","funders":"National Research Council Canada; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; Bifunctional; Biodistribution; Chelation; In vivo; Ligand (biochemistry); Conjugated system; DOTA; Spect imaging; Preclinical imaging; Radiochemistry; Stereochemistry; Nuclear chemistry; In vitro; Nuclear medicine; Inorganic chemistry; Organic chemistry; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001978653,0.0005623539,0.001096209,0.000183135,0.0003781684,0.00006222375,0.0004811384,0.0004923893,0.0005078145],"category_scores_gemma":[0.003558283,0.0004667132,0.0006430324,0.000911606,0.0004059362,0.0001645289,0.00009167703,0.001773953,0.00007711837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003471351,"about_ca_system_score_gemma":0.000719282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001251654,"about_ca_topic_score_gemma":4.41977e-8,"domain_scores_codex":[0.9950431,0.00007024555,0.001772186,0.0006403716,0.001593821,0.0008802552],"domain_scores_gemma":[0.9945958,0.00214488,0.000631766,0.0005212008,0.0008101226,0.001296254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00176629,0.0003973428,0.0006932645,0.001107352,0.0005662044,0.0003981673,0.0003349399,0.00253066,0.9445803,0.00001612088,0.04034527,0.007264055],"study_design_scores_gemma":[0.01058023,0.0003839449,0.0007069442,0.001402647,0.001486875,0.007369389,0.0009317119,0.04376636,0.9063641,0.0007244126,0.02572995,0.0005533767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849018,0.001506391,0.001046682,0.008912016,0.0001889193,0.0006760805,0.00006864269,0.0001553499,0.002544078],"genre_scores_gemma":[0.9901568,0.000946998,0.0008400395,0.001038065,0.005297142,0.0001054381,0.000137431,0.0001087717,0.001369276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0412357,"threshold_uncertainty_score":0.9997784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04880465568498497,"score_gpt":0.3493588462342277,"score_spread":0.3005541905492428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}