{"id":"W4386950405","doi":"10.1021/acs.jmedchem.3c01151","title":"Rearmed Bifunctional Chelating Ligand for <sup>225</sup>Ac/<sup>155</sup>Tb Precision-Guided Theranostic Radiopharmaceuticals─H<sub>4</sub>noneunpaX","year":2023,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of British Columbia; TRIUMF","funders":"National Research Council Canada; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; Bifunctional; Biodistribution; Chelation; In vivo; Ligand (biochemistry); Conjugated system; DOTA; Spect imaging; Preclinical imaging; Radiochemistry; Stereochemistry; Nuclear chemistry; In vitro; Nuclear medicine; Inorganic chemistry; Organic chemistry; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000914108,0.0002956351,0.0001423762,0.00008903099,0.000121843,0.0002252445,0.0002558739,0.0002565315,0.001957724],"category_scores_gemma":[0.00006749376,0.0001030199,0.00009108285,0.00006487778,0.0001826523,0.000153974,0.000189871,0.0002739767,0.0007555935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002895634,"about_ca_system_score_gemma":0.0001597097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005112226,"about_ca_topic_score_gemma":0.0006024003,"domain_scores_codex":[0.9999454,0.000008093135,0.000002973434,0.00001169922,0.00001705494,0.00001472279],"domain_scores_gemma":[0.9999678,0.000004637958,0.00001003054,0.000003001386,0.000007746316,0.00000674766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007178217,0.00001036949,0.00009052578,0.00004634057,0.000002904249,0.00003842981,0.00001262512,0.0001653297,0.9950983,0.0005093202,0.0001726322,0.003781546],"study_design_scores_gemma":[0.00001118352,0.0001184274,0.0003731613,0.000003429193,0.000007971295,0.0001314531,0.00001352504,0.001413827,0.9926218,0.00003760463,0.005260078,0.000007497829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9728966,0.001488874,0.01682327,0.0002138374,0.00004720691,0.00004108007,0.0002310656,0.0003682872,0.007889775],"genre_scores_gemma":[0.9778901,0.0004374293,0.01347648,0.0001381959,0.00001091592,0.00004352291,0.0002708231,0.00003498051,0.007697614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001957724,"threshold_uncertainty_score":0.00654918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04880465568498497,"score_gpt":0.3493588462342277,"score_spread":0.3005541905492428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}