{"id":"W4386958471","doi":"10.1038/s41576-023-00648-z","title":"Pioneer factors — key regulators of chromatin and gene expression","year":2023,"lang":"en","type":"review","venue":"Nature Reviews Genetics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Human Genome Research Institute; Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; National Institutes of Health; Cancer Research UK; Compute Canada","keywords":"Reprogramming; Chromatin; Cell fate determination; Biology; Regulation of gene expression; Gene expression; Transcription factor; Cellular differentiation; Gene; Cell biology; Computational biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0003888474,0.0006452562,0.001839259,0.0001337698,0.00006881353,0.00002750657,0.0004888801,0.00165648,0.00001079311],"category_scores_gemma":[0.0001804368,0.0004836689,0.0006070198,0.0002727838,0.00009433624,0.000001950493,0.0004577083,0.0005018895,0.00001354949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002952722,"about_ca_system_score_gemma":0.0001507804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001226026,"about_ca_topic_score_gemma":0.000005413614,"domain_scores_codex":[0.997426,0.0002101619,0.001127145,0.0006888671,0.0002321832,0.0003156467],"domain_scores_gemma":[0.9977626,0.00004056867,0.000947176,0.001014489,0.00008854281,0.0001466591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000007636503,0.0001146151,0.00009920936,0.07828902,0.0005506734,0.000006754968,0.0001212249,0.00001551141,0.02400578,0.00008261988,0.01124586,0.8854611],"study_design_scores_gemma":[0.0001066927,0.00008693815,0.00002677645,0.005170446,0.0004122258,0.00002102776,0.000007139839,0.000008399452,0.002527563,0.00002598537,0.991131,0.0004757766],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003888818,0.9943628,0.00005876839,0.000003078439,0.0003568547,0.001045215,0.0002099393,0.00001598875,0.00005853855],"genre_scores_gemma":[0.00008081216,0.9932008,0.004709426,0.00001905334,0.0002762627,0.00005210132,0.001170255,0.0001494623,0.0003418112],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9798852,"threshold_uncertainty_score":0.9997615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0237562629755877,"score_gpt":0.3102291509100725,"score_spread":0.2864728879344848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}