{"id":"W4386964532","doi":"10.1101/2023.09.19.558428","title":"Etifoxine inhibits NLRP3 inflammasome activity in human and murine myeloid cells","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Medical Research Council; Multiple Sclerosis Society; Multiple Sclerosis Society of Canada; European Genomic Institute for Diabetes","keywords":"Inflammasome; Translocator protein; Microglia; CD14; Neuroinflammation; Immunology; Immune system; Chemistry; Cell biology; Inflammation; Pharmacology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001997693,0.0002467424,0.0002271049,0.0002062789,0.00009637121,0.000187873,0.0001133168,0.0001761528,0.000883488],"category_scores_gemma":[0.0001115106,0.00005461375,0.0001626961,0.0001426099,0.0001383439,0.00007668293,0.0001156863,0.0002826478,0.0001862055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001411357,"about_ca_system_score_gemma":0.0001943282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003561236,"about_ca_topic_score_gemma":0.0006343013,"domain_scores_codex":[0.9998689,0.00003338423,0.00001838225,0.00001950238,0.00002672093,0.00003321575],"domain_scores_gemma":[0.9999408,0.00001810495,0.00001432084,0.000007825957,0.000007633435,0.00001134219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006213591,0.0001262361,0.0001677586,0.00007943863,0.00000715625,0.00005564422,0.00002260379,0.0001104429,0.9968544,0.00005330516,0.00005850013,0.001843288],"study_design_scores_gemma":[0.00009540506,0.002320809,0.002239513,0.000008503514,0.0000217149,0.0002670167,0.00003016644,0.000519358,0.9913654,0.00002515376,0.003103239,0.000003731186],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934939,0.002528481,0.002230898,0.00008379406,0.00002457023,0.00005535461,0.0005161561,0.00004181718,0.001025173],"genre_scores_gemma":[0.9931571,0.001811419,0.002464072,0.00006803025,0.00001985075,0.00009080414,0.0007654198,0.00000768826,0.001615619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000883488,"threshold_uncertainty_score":0.002955556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01042190617827684,"score_gpt":0.219660544131155,"score_spread":0.2092386379528782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}