{"id":"W4386977179","doi":"10.3390/cimb45100486","title":"Targeted Delivery of Chimeric Antigen Receptor into T Cells via CRISPR-Mediated Homology-Directed Repair with a Dual-AAV6 Transduction System","year":2023,"lang":"en","type":"review","venue":"Current Issues in Molecular Biology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de Recherche du Québec - Santé; Canada Research Chairs","keywords":"Chimeric antigen receptor; CRISPR; Insertional mutagenesis; Transduction (biophysics); Biology; Homology directed repair; Cell biology; T cell; Molecular biology; Genetics; Gene; DNA repair; Immune system; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002716675,0.0005690484,0.000664623,0.001096497,0.00008559183,0.0004427229,0.0005416896,0.0005735882,0.00136376],"category_scores_gemma":[0.0001270582,0.0001814636,0.0003118113,0.0006734472,0.0002018481,0.0004627548,0.0002920991,0.0009113624,0.001280278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003685199,"about_ca_system_score_gemma":0.0003680766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004218446,"about_ca_topic_score_gemma":0.000548086,"domain_scores_codex":[0.999896,0.00001555584,0.000008931415,0.00002068556,0.00004494629,0.00001381843],"domain_scores_gemma":[0.9999617,0.00001141495,0.000007969542,0.000001970293,0.00001087731,0.000006091851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001055382,0.0001449417,0.0001475862,0.01096833,0.0001289598,0.0004817215,0.00004851754,0.0007887554,0.08244697,0.005221277,0.01820199,0.8813154],"study_design_scores_gemma":[0.00006985124,0.0003448392,0.001055083,0.0009801745,0.0001680191,0.003939109,0.00003602774,0.0005249211,0.03087002,0.001280666,0.960694,0.0000373143],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001723557,0.9913317,0.002961506,0.0002775556,0.0002611337,0.00003050918,0.00004405707,0.00008159698,0.003288388],"genre_scores_gemma":[0.008139582,0.9858416,0.002549623,0.000280839,0.0001387303,0.00003426184,0.0001279237,0.000008004761,0.00287934],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00136376,"threshold_uncertainty_score":0.004562199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03301138151884226,"score_gpt":0.3740457775648992,"score_spread":0.3410343960460569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}