{"id":"W4386979509","doi":"10.1016/j.celrep.2023.113128","title":"Pannexin-1 opening in neuronal edema causes cell death but also leads to protection via increased microglia contacts","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Université de Montréal; University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; National Institutes of Health; Killam Trusts; Norges Idrettshøgskole; Fondation Leducq; Michael Smith Health Research BC; Université Laval","keywords":"Microglia; Pannexin; Autophagy; Programmed cell death; Edema; Cell biology; Medicine; Neuroinflammation; Neuroscience; Biology; Gap junction; Chemistry; Inflammation; Immunology; Intracellular; Apoptosis; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001403093,0.0004055167,0.0004486634,0.0001405694,0.0002224399,0.0003077029,0.0001389208,0.0004567877,0.00168976],"category_scores_gemma":[0.0001112761,0.0001013939,0.0002627774,0.0001201573,0.000283177,0.0007098612,0.0002373185,0.0006900672,0.0001972617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003199241,"about_ca_system_score_gemma":0.0001714368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002615541,"about_ca_topic_score_gemma":0.0005228185,"domain_scores_codex":[0.999871,0.000015369,0.00001118811,0.0000279938,0.00003273906,0.00004160635],"domain_scores_gemma":[0.9999106,0.00001358108,0.00003164349,0.000008836266,0.00001195921,0.00002341522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000171701,0.00002816082,0.0002362608,0.0000930117,0.000009348841,0.0001878112,0.00002845006,0.00003624341,0.9977569,0.0001423981,0.00003778983,0.001271865],"study_design_scores_gemma":[0.00002028323,0.0004587058,0.01195835,0.00001473105,0.0000228905,0.0005598745,0.0001064619,0.0003473566,0.9849222,0.0002678843,0.001316789,0.000004433668],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928619,0.003697528,0.001588047,0.0001934222,0.00005077434,0.00002084075,0.0001297302,0.00006932058,0.0013885],"genre_scores_gemma":[0.9962005,0.00139126,0.0008002737,0.00006726751,0.00001511352,0.00002583443,0.0001007397,0.000006092563,0.001392885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00168976,"threshold_uncertainty_score":0.005652845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01817418185019074,"score_gpt":0.2486555791067385,"score_spread":0.2304813972565478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}