{"id":"W4386979509","doi":"10.1016/j.celrep.2023.113128","title":"Pannexin-1 opening in neuronal edema causes cell death but also leads to protection via increased microglia contacts","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Université de Montréal; University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; National Institutes of Health; Killam Trusts; Norges Idrettshøgskole; Fondation Leducq; Michael Smith Health Research BC; Université Laval","keywords":"Microglia; Pannexin; Autophagy; Programmed cell death; Edema; Cell biology; Medicine; Neuroinflammation; Neuroscience; Biology; Gap junction; Chemistry; Inflammation; Immunology; Intracellular; Apoptosis; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003626178,0.0002127888,0.0002301831,0.0001307266,0.0000862384,0.00002990802,0.0001127952,0.0002158699,0.00003286272],"category_scores_gemma":[0.0001286009,0.0002117531,0.00008632861,0.0001835314,0.00003017138,0.000005111708,0.0001932541,0.0001414621,0.00005275611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002845967,"about_ca_system_score_gemma":0.0001505131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001039661,"about_ca_topic_score_gemma":0.0003293942,"domain_scores_codex":[0.9983194,0.0001024175,0.0004007522,0.0006486193,0.0001029216,0.0004258477],"domain_scores_gemma":[0.9991938,0.00001832069,0.0001571384,0.0004105841,0.00007363268,0.0001465605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001007881,0.00005679805,0.02329687,0.00002579702,0.000007275661,0.0005631924,0.00003971453,0.00006686869,0.9744911,0.000001258455,0.0008636661,0.0004866644],"study_design_scores_gemma":[0.0003626465,0.0003921749,0.03039756,0.00001541231,0.00001168337,0.0001737041,0.00004464723,0.00004425961,0.9417418,0.00002545692,0.02652307,0.0002675569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973419,0.0001420604,0.0002257176,0.0001111436,0.0003431991,0.0005445298,0.000007814326,0.00004266494,0.001241011],"genre_scores_gemma":[0.9954424,0.00003912487,0.0001364999,0.0004230644,0.0001957566,0.00009881351,0.0001643194,0.00003562574,0.003464412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03274928,"threshold_uncertainty_score":0.8635042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01817418185019074,"score_gpt":0.2486555791067385,"score_spread":0.2304813972565478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}