{"id":"W4386979591","doi":"10.1093/hmg/ddad160","title":"Higher incidence of embryonic defects in mouse offspring conceived with assisted reproduction from fathers with sperm epimutations","year":2023,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada; McGill University; McGill University Health Centre","funders":"Health Canada; Canadian Institutes of Health Research; Genome Canada; Alliance de recherche numérique du Canada; Génome Québec; McGill University","keywords":"Biology; Offspring; Haploinsufficiency; Reproductive technology; DNA methylation; Epigenetics; Andrology; Genomic imprinting; Embryo; Sperm; Infertility; Genetics; Epigenome; Fertilisation; Assisted reproductive technology; Embryo culture; Pregnancy; Embryogenesis; Phenotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001267975,0.0001937105,0.0002052418,0.0001067697,0.00006520847,0.00002386669,0.0001902884,0.0001065116,0.00001312268],"category_scores_gemma":[0.00003208877,0.0001835725,0.00005632746,0.000323365,0.0001345734,0.000004033019,0.00009952276,0.000102463,0.000006950293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002106653,"about_ca_system_score_gemma":0.00007632077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000122967,"about_ca_topic_score_gemma":0.000225229,"domain_scores_codex":[0.9985944,0.00007598861,0.0002614392,0.0005612153,0.0002238635,0.000283106],"domain_scores_gemma":[0.9990097,0.00001068091,0.000166143,0.0006324472,0.000117738,0.00006330464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001633569,0.00003996391,0.03588675,0.0000188664,0.00006816705,0.00001967516,0.0001406587,0.0111907,0.9521993,0.00003482468,0.00001225986,0.0003725088],"study_design_scores_gemma":[0.0008182538,0.0004010092,0.4540074,0.00005702642,0.00003836275,0.00001221784,0.0002126909,0.0001502666,0.5438501,0.00005549767,0.0001667723,0.0002304622],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978513,0.0004570366,0.001076505,0.00003484343,0.00004559942,0.0002697148,0.000008059465,0.00002601484,0.0002309363],"genre_scores_gemma":[0.9963255,0.00006873313,0.002933579,0.00003186642,0.00004223383,0.00002744083,0.0001163273,0.00005409288,0.0004002533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4181207,"threshold_uncertainty_score":0.7485867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0183436499955824,"score_gpt":0.2577326108397527,"score_spread":0.2393889608441703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}