{"id":"W4386985621","doi":"10.1186/s13223-023-00840-0","title":"Two cases of successful sirolimus treatment for patients with activated phosphoinositide 3-kinase δ syndrome 1","year":2023,"lang":"en","type":"article","venue":"Allergy Asthma and Clinical Immunology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Science and Technology Program of Suzhou; Soochow University","keywords":"Sirolimus; Phosphoinositide 3-kinase; Medicine; Kinase; Cancer research; PI3K/AKT/mTOR pathway; Oncology; Internal medicine; Cell biology; Signal transduction; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002199526,0.0003415999,0.0007923474,0.00016283,0.0003129179,0.00001144639,0.0002629149,0.0003668492,0.000188206],"category_scores_gemma":[0.0001895989,0.0002616721,0.0002367323,0.0003045016,0.000950933,0.0001159052,0.0001271459,0.0002447078,0.00009928435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002654388,"about_ca_system_score_gemma":0.00009587655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006346439,"about_ca_topic_score_gemma":0.00004724206,"domain_scores_codex":[0.9977441,0.0002543945,0.0007673677,0.0005492578,0.00004567042,0.000639233],"domain_scores_gemma":[0.9976661,0.00139511,0.0003293033,0.0004331258,0.0001581555,0.00001816472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.05324173,0.02378743,0.1699981,0.0002387515,0.03120691,0.0006024943,0.002632161,0.000286131,0.1437571,0.0132818,0.0008814677,0.5600859],"study_design_scores_gemma":[0.03562029,0.02282653,0.8583144,0.0001431105,0.0002120797,0.0002195509,0.001625003,0.00002523198,0.0182309,0.000323754,0.0615704,0.0008887547],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923692,0.005873739,0.00001729129,0.0001621114,0.0006707836,0.0005078967,0.0001107947,0.0001276569,0.000160517],"genre_scores_gemma":[0.9966524,0.001478052,0.00003598355,0.00007807971,0.000004064004,0.0001032115,0.0007383127,0.0000356267,0.0008743074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6883163,"threshold_uncertainty_score":0.9999835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01558553274962974,"score_gpt":0.2837048833458422,"score_spread":0.2681193505962124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}