{"id":"W4386996072","doi":"10.3390/cancers15194703","title":"Dual-Armed Oncolytic Myxoma Virus Encoding IFN-γ and CD47 Promotes Lymphocyte Infiltration and Tumor Suppression of Syngeneic Murine Melanoma","year":2023,"lang":"en","type":"article","venue":"Cancers","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa","funders":"National Institute of Environmental Health Sciences; Korea Health Industry Development Institute","keywords":"Myxoma virus; Oncolytic virus; Melanoma; Immunotherapy; CD47; Immune system; Cancer research; Immunology; Medicine; Biology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001273945,0.0003864692,0.0002048904,0.0002132435,0.00007962934,0.0001899027,0.0001416147,0.0002717589,0.000716931],"category_scores_gemma":[0.00005780381,0.0001373228,0.000217025,0.00009149155,0.0001443647,0.0001892713,0.0001418489,0.000759692,0.0002134949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001386027,"about_ca_system_score_gemma":0.0001256132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002695313,"about_ca_topic_score_gemma":0.0004239767,"domain_scores_codex":[0.999869,0.00002039424,0.00001237648,0.00003052628,0.00003018002,0.00003750209],"domain_scores_gemma":[0.9999323,0.000008299287,0.00002029709,0.000008661596,0.000005557337,0.00002490153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001345546,0.00007204155,0.00007094609,0.00001889259,0.00000249267,0.00001863045,0.00001486686,0.00003744148,0.9989331,0.00005574962,0.00002493503,0.0006162694],"study_design_scores_gemma":[0.00004854888,0.001545248,0.001774698,0.000007007382,0.00001393768,0.0001466157,0.00002058608,0.001165615,0.9939768,0.00003374592,0.001264425,0.000002641603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996752,0.0006532891,0.001220746,0.00004621766,0.00003003875,0.00003997952,0.0001726285,0.00005855524,0.001026456],"genre_scores_gemma":[0.9957464,0.0003471595,0.001136567,0.00002839284,0.00001047159,0.00004778681,0.0002288709,0.00001175191,0.002442702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000716931,"threshold_uncertainty_score":0.002398372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01885256471004142,"score_gpt":0.2972203545797737,"score_spread":0.2783677898697323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}