{"id":"W4386997034","doi":"10.3390/cells12192344","title":"Overexpression of FRA1 (FOSL1) Leads to Global Transcriptional Perturbations, Reduced Cellular Adhesion and Altered Cell Cycle Progression","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences North; Lakehead University; NOSM University; Laurentian University","funders":"Bruce Power","keywords":"Biology; Cell biology; Transcription factor; Cell adhesion; Cell cycle; Transcriptional regulation; Cancer research; Cell; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002660172,0.0001989964,0.0003110264,0.0002180511,0.0001165798,0.00002527317,0.0001477954,0.0001697168,0.0003852737],"category_scores_gemma":[0.00007614759,0.0001701235,0.000117452,0.0006527968,0.00008756593,0.0000751988,0.0001440329,0.0001979688,0.0002820678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008970566,"about_ca_system_score_gemma":0.0001343842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001358088,"about_ca_topic_score_gemma":7.197086e-7,"domain_scores_codex":[0.997803,0.0001055938,0.0003830259,0.0004887454,0.0008328562,0.0003867197],"domain_scores_gemma":[0.9988685,0.000082367,0.00008019909,0.000396511,0.0001658189,0.0004066594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003997106,0.0002213174,0.001438916,0.0003288417,0.00000825292,0.00002522529,0.0002289888,0.0000445954,0.982546,0.00004255931,0.01121598,0.00349956],"study_design_scores_gemma":[0.001362658,0.0005404059,0.02182226,0.0004452817,0.0000293036,0.000006942935,0.0001291588,0.001582901,0.9700024,0.0001515058,0.00376135,0.0001658203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952381,0.0004891763,0.0001691932,0.0007462405,0.0001708875,0.0009860615,0.00005023208,0.00009898097,0.002051136],"genre_scores_gemma":[0.9941432,0.0001623846,0.002052026,0.0001273317,0.0001244536,0.00005822367,0.0001412086,0.00003339188,0.003157821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02038334,"threshold_uncertainty_score":0.6937435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02325025830241662,"score_gpt":0.3180750372960663,"score_spread":0.2948247789936497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}