{"id":"W4386998234","doi":"10.31083/j.rcm2409264","title":"Status of β1-Adrenoceptor Signal Transduction System in Cardiac Hypertrophy and Heart Failure","year":2023,"lang":"en","type":"review","venue":"Reviews in Cardiovascular Medicine","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"","keywords":"Pressure overload; Heart failure; Muscle hypertrophy; Internal medicine; Medicine; Volume overload; Cardiology; Downregulation and upregulation; Signal transduction; Cardiac function curve; Endocrinology; Cardiac hypertrophy; Cell biology; Chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003535294,0.0002288331,0.0003033034,0.0006469489,0.0001379202,0.0002598265,0.0002162109,0.0003145546,0.0003651023],"category_scores_gemma":[0.0001512539,0.00009892041,0.0001902571,0.0002436332,0.0002513847,0.0003290137,0.0001872742,0.0003835683,0.0001180894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002002279,"about_ca_system_score_gemma":0.0001876363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002856282,"about_ca_topic_score_gemma":0.0002409425,"domain_scores_codex":[0.999894,0.00002078054,0.00001524847,0.00001687788,0.00002566334,0.00002743838],"domain_scores_gemma":[0.9998852,0.00003046564,0.00003643055,0.000006506143,0.00002154669,0.00001971276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001156724,0.0001225438,0.01543355,0.001638965,0.00009564194,0.002003964,0.0003724043,0.0002994113,0.925455,0.0007659832,0.0002884396,0.05236745],"study_design_scores_gemma":[0.0001034992,0.003980736,0.6330776,0.0004450047,0.0006225185,0.009519498,0.0007909071,0.001235726,0.3160522,0.002859617,0.03120528,0.0001074234],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.7117459,0.2809857,0.002756753,0.0005379925,0.0001020998,0.00002736634,0.0002456198,0.00006020148,0.003538363],"genre_scores_gemma":[0.8840768,0.1121804,0.001158725,0.0002294376,0.0002457767,0.00004323249,0.000532336,0.00000814906,0.001525074],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.0006469489,"threshold_uncertainty_score":0.001869678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03661843132512417,"score_gpt":0.2957154345178771,"score_spread":0.2590970031927529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}