{"id":"W4386998400","doi":"10.1101/2023.09.23.559106","title":"Sex-based disparities in DNA methylation and gene expression in late-gestation mouse placentas","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Cegep Edouard Montpetit; Centre Hospitalier Universitaire Sainte-Justine","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Centre de recherche du CHU Sainte-Justine; Université de Montréal","keywords":"Biology; DNA methylation; Differentially methylated regions; Epigenetics; CpG site; Autosome; Placenta; Methylation; Placentation; Offspring; Genetics; Fetus; X chromosome; Andrology; Gene; Gene expression; Pregnancy; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002341432,0.0001813005,0.0002232699,0.00109181,0.0001603035,0.0003213872,0.0001407648,0.0002249629,0.001413269],"category_scores_gemma":[0.0002211856,0.0002295597,0.0002659619,0.0003797886,0.0002174729,0.0001416939,0.0002629326,0.0003182798,0.0002000741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001647386,"about_ca_system_score_gemma":0.0001225168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008295568,"about_ca_topic_score_gemma":0.001239425,"domain_scores_codex":[0.9997622,0.00002338974,0.00001723019,0.0001069373,0.00004582127,0.00004438009],"domain_scores_gemma":[0.999801,0.00002268254,0.00008609465,0.000022125,0.00003035699,0.00003779069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003675653,0.00001366988,0.01782562,0.00005303042,0.00003932323,0.00007318596,0.0001086475,0.00004902577,0.9771647,0.0001321677,0.000073272,0.004099851],"study_design_scores_gemma":[0.00003317378,0.0003813549,0.6447431,0.00003712701,0.0001296444,0.001028716,0.000313851,0.001083834,0.3474765,0.0005291921,0.004216799,0.0000266599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921238,0.001847896,0.003165677,0.00005127678,0.00001484968,0.00001255331,0.001909042,0.0000708502,0.0008039969],"genre_scores_gemma":[0.9929484,0.0008918493,0.002300568,0.0001224384,0.000009651379,0.00005065827,0.001545058,0.00005998609,0.002071216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001413269,"threshold_uncertainty_score":0.00472784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01668837334742663,"score_gpt":0.240160620162933,"score_spread":0.2234722468155064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}