{"id":"W4387001849","doi":"10.1128/jvi.00828-23","title":"Reovirus genomic diversity confers plasticity for protease utility during adaptation to intracellular uncoating","year":2023,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Viral gastroenteritis research and epidemiology","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Provincial Laboratory of Public Health; University of Alberta","funders":"Faculty of Medicine and Dentistry, University of Alberta; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates; Canada Foundation for Innovation; University of Alberta; Canada Research Chairs; Government of Canada","keywords":"Biology; Proteases; Infectivity; Reoviridae; Intracellular; Protease; Virology; Capsid; Extracellular; Virus; Cell biology; Biochemistry; Enzyme; Rotavirus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002548863,0.0003060864,0.0002620124,0.0002981534,0.0001129746,0.0004951329,0.0002476493,0.0002626867,0.0006520763],"category_scores_gemma":[0.0004852659,0.0001444297,0.0003911591,0.0002341271,0.0002553419,0.0002438598,0.0003626578,0.0006196529,0.0002693559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002200719,"about_ca_system_score_gemma":0.0001173042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006437804,"about_ca_topic_score_gemma":0.000751248,"domain_scores_codex":[0.9997151,0.00005333104,0.00003447708,0.00006312753,0.00005655106,0.00007736995],"domain_scores_gemma":[0.9996203,0.0001109888,0.00008501784,0.00007535575,0.00005093956,0.00005745626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000587265,0.00001148093,0.000628366,0.00001101015,0.000005432886,0.00003945076,0.00001928555,0.00004421661,0.9986154,0.00002433425,0.00001112002,0.0005311127],"study_design_scores_gemma":[0.00001060337,0.0004243232,0.02721631,0.00001073123,0.00003636751,0.001007952,0.0001474529,0.001327749,0.9684272,0.00007218555,0.001298584,0.00002059495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981591,0.0001553875,0.001073794,0.0000129427,0.000005335852,0.000008297489,0.0002632273,0.00002788052,0.0002939967],"genre_scores_gemma":[0.9974941,0.00007622965,0.001271833,0.00001801658,0.000002476988,0.00001277382,0.0007613822,0.00003556755,0.0003276035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006520763,"threshold_uncertainty_score":0.002181411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0751022925581867,"score_gpt":0.3291110430353893,"score_spread":0.2540087504772026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}