{"id":"W4387004108","doi":"10.1016/s2152-2650(23)01644-0","title":"P-026 Safety and efficacy of a locally produced novel anti-BCMA chimeric antigen receptor T-cell (CART) (HBI0101) for the treatment of relapsed and refractory multiple myeloma","year":2023,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"National Research Council Canada; Terry Fox Research Institute; University of Calgary","funders":"","keywords":"Chimeric antigen receptor; Cart; Multiple myeloma; Refractory (planetary science); Medicine; Antigen; Receptor; Cancer research; Virology; Immunotherapy; Immunology; Internal medicine; Biology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002714971,0.0002541976,0.0006322101,0.000203557,0.0002005709,0.0005310276,0.0003879559,0.0004891197,0.002119771],"category_scores_gemma":[0.0002789712,0.0001255682,0.0003484104,0.0002223852,0.0004223136,0.0003206597,0.0001200777,0.001505302,0.0005237577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000436208,"about_ca_system_score_gemma":0.0005389056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0015521,"about_ca_topic_score_gemma":0.00157203,"domain_scores_codex":[0.9998831,0.00003906944,0.00000543973,0.00001814832,0.00001941803,0.00003474689],"domain_scores_gemma":[0.9998953,0.00002257784,0.0000153846,0.00001509282,0.00000675236,0.00004486592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1661779,0.02599019,0.005986357,0.0006909129,0.0005745689,0.001450967,0.0003772384,0.005075959,0.370811,0.001400518,0.004144306,0.4173201],"study_design_scores_gemma":[0.07210498,0.650408,0.04648881,0.00009642989,0.0009866089,0.004235983,0.0002105911,0.01231188,0.1938184,0.0005763594,0.01866544,0.00009659178],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950278,0.002055499,0.0004140215,0.0001757133,0.00005697584,0.00009088274,0.0002332009,0.00007911157,0.001866865],"genre_scores_gemma":[0.9976436,0.000516152,0.0002126577,0.00008430889,0.00003465409,0.00004283999,0.000331698,0.00001099697,0.001123037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002119771,"threshold_uncertainty_score":0.007091343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04908132357785517,"score_gpt":0.3419095608909767,"score_spread":0.2928282373131216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}