{"id":"W4387004956","doi":"10.1016/j.ijpharm.2023.123448","title":"Aptamer-based targeted delivery systems for cancer treatment using DNA origami and DNA nanostructures","year":2023,"lang":"en","type":"review","venue":"International Journal of Pharmaceutics","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"Mashhad University of Medical Sciences","keywords":"Aptamer; Nanocarriers; Nanomedicine; Nanotechnology; DNA origami; DNA; Drug delivery; Cancer therapy; Targeted drug delivery; Biocompatibility; Cancer; Materials science; Computational biology; Nanostructure; Chemistry; Nanoparticle; Biology; Molecular biology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002726515,0.000751331,0.0007365384,0.0007694359,0.0001164219,0.0004861444,0.0007198979,0.0007561183,0.001577515],"category_scores_gemma":[0.0002073615,0.0002577477,0.000299463,0.00085268,0.0002048963,0.0006045875,0.0003716165,0.001093339,0.00126025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003858467,"about_ca_system_score_gemma":0.0003616597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006571101,"about_ca_topic_score_gemma":0.001226892,"domain_scores_codex":[0.999913,0.00000754497,0.000005888257,0.00001837791,0.00004271713,0.00001256072],"domain_scores_gemma":[0.9999524,0.00001681283,0.00001056363,0.000001936865,0.00001319146,0.000004920214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001054292,0.0001540566,0.00006153881,0.008477369,0.00007731795,0.0001699569,0.00004129763,0.000765643,0.0468303,0.004237506,0.01705213,0.9220274],"study_design_scores_gemma":[0.00004278247,0.000358957,0.0006173818,0.0009508122,0.0001327555,0.0008469496,0.00003604027,0.0006527804,0.02524509,0.001318275,0.9697579,0.00004034032],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001030923,0.9948764,0.001416579,0.000150561,0.0003029831,0.00001924969,0.00003647728,0.00003254173,0.002134236],"genre_scores_gemma":[0.005172662,0.98727,0.001702919,0.0003063319,0.0001575088,0.00003303753,0.0000913131,0.000006045834,0.005260189],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001577515,"threshold_uncertainty_score":0.005277336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1046474438140848,"score_gpt":0.4499148694007876,"score_spread":0.3452674255867028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}