{"id":"W4387005274","doi":"10.1101/2023.09.25.557123","title":"Bmp9 regulates Notch signaling and the temporal dynamics of angiogenesis via Lunatic Fringe","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; China Scholarship Council; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; Francis Crick Institute; British Heart Foundation; National Institutes of Health; Cancer Research UK; Medical Research Council; American Heart Association","keywords":"Lunatic; Dynamics (music); Notch signaling pathway; Angiogenesis; Neuroscience; Biology; Political science; Cell biology; Medicine; Law; Physics; Internal medicine; Signal transduction; Acoustics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007663777,0.0003474609,0.0004072445,0.0001151674,0.0001414352,0.00003947244,0.0003339838,0.0005675584,0.000004947071],"category_scores_gemma":[0.0001169352,0.0002953526,0.000159711,0.0002066828,0.000362491,0.00000522973,0.0006215108,0.0001832528,0.000005861383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004577745,"about_ca_system_score_gemma":0.0001706392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005751578,"about_ca_topic_score_gemma":0.00002145317,"domain_scores_codex":[0.9982885,0.0001560521,0.0004603505,0.0006423258,0.0001671692,0.0002855981],"domain_scores_gemma":[0.9986431,0.00005057333,0.0003764855,0.0006426574,0.0002082273,0.00007897663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001485763,0.00003498657,0.03086567,0.0002748347,0.0004317388,0.000004915088,0.000011581,0.0002133452,0.9676465,0.000240616,0.0001153044,0.0000119476],"study_design_scores_gemma":[0.000835845,0.00005529725,0.1133423,0.000173117,0.0001622892,7.735144e-8,0.000007537821,0.001944399,0.8825477,0.00005201144,0.0003417543,0.000537703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944792,0.002025169,0.001939674,0.000333748,0.0005659108,0.0004865878,0.0001096893,0.0000571504,0.000002865409],"genre_scores_gemma":[0.9967266,0.0003614642,0.002442088,0.00006005177,0.0002164027,0.00008278782,0.00001285413,0.00006806245,0.00002966354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08509882,"threshold_uncertainty_score":0.9999499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008456929469619966,"score_gpt":0.2060451293647182,"score_spread":0.1975881998950982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}