{"id":"W4387008045","doi":"10.1016/j.freeradbiomed.2023.09.029","title":"The glyoxylate shunt protein ICL-1 protects from mitochondrial superoxide stress through activation of the mitochondrial unfolded protein response","year":2023,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre; Montreal Neurological Institute and Hospital","funders":"National Institute on Aging; National Institutes of Health","keywords":"Mitochondrion; Glyoxylate cycle; SOD2; Cell biology; Biology; Citric acid cycle; Superoxide dismutase; Superoxide; Lethality; Aconitase; Biochemistry; Oxidative stress; Genetics; Metabolism; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001332715,0.0003055761,0.0002517221,0.0001577903,0.0002128449,0.000287461,0.0002191773,0.0002755377,0.0007278908],"category_scores_gemma":[0.0001484992,0.0001087991,0.000153108,0.0001135963,0.0002787231,0.000176158,0.0001953509,0.0005790642,0.000243056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004557927,"about_ca_system_score_gemma":0.0002744617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003872287,"about_ca_topic_score_gemma":0.0005065645,"domain_scores_codex":[0.9999403,0.000007550474,0.000003684572,0.00001930955,0.00001330318,0.00001586526],"domain_scores_gemma":[0.9998453,0.00001359873,0.00006748897,0.00001317592,0.000011394,0.00004908021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003422642,0.00002812009,0.0002096143,0.00002184531,0.000006233471,0.00004481795,0.000006902068,0.00007487278,0.9979988,0.0001311924,0.0001008785,0.001034421],"study_design_scores_gemma":[0.00006581558,0.0002462734,0.004470962,0.000005956826,0.000015588,0.000227592,0.00001667392,0.000982971,0.991184,0.0001775031,0.002598503,0.000008157654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944376,0.001636784,0.00225559,0.0005151966,0.00007644456,0.00001405841,0.0002899831,0.0001392863,0.0006350378],"genre_scores_gemma":[0.9957034,0.0006904616,0.001718998,0.0001278406,0.00002880068,0.00001259965,0.0005566371,0.00003083935,0.001130303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007278908,"threshold_uncertainty_score":0.003307045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01246284601408034,"score_gpt":0.256649582278826,"score_spread":0.2441867362647457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}