{"id":"W4387008412","doi":"10.2139/ssrn.4574067","title":"Presentation and Outcomes of KRAS<sup>G12C</sup> Mutant Non-Small Cell Lung Cancer Patients with Stage IV Disease at Diagnosis (de novo) Versus at Recurrence","year":2023,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Dalhousie University; Princess Margaret Cancer Centre","funders":"","keywords":"KRAS; Stage (stratigraphy); Medicine; Disease; Presentation (obstetrics); Cell; Cancer; Lung cancer; Internal medicine; Cancer research; Oncology; Biology; Surgery; Genetics; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002167085,0.0002358543,0.0004402477,0.0006109343,0.0002936919,0.0008148693,0.0004045181,0.0007200897,0.006881731],"category_scores_gemma":[0.001471222,0.0001771264,0.0007812224,0.0006976427,0.0002619045,0.000960084,0.0006199548,0.0008414159,0.001041368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005068714,"about_ca_system_score_gemma":0.000350071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002966853,"about_ca_topic_score_gemma":0.003047734,"domain_scores_codex":[0.9996907,0.00002624755,0.00002617146,0.0000906061,0.00002764424,0.0001385928],"domain_scores_gemma":[0.9991589,0.0001235838,0.0003033997,0.00004053145,0.000076378,0.0002973033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001759056,0.00006462978,0.9914216,0.00002998858,0.000113795,0.0005731523,0.0001231384,0.0001780008,0.0004105305,0.0001296631,0.0009306364,0.004265759],"study_design_scores_gemma":[0.00002507225,0.0003336011,0.9966908,0.00001930583,0.00006767183,0.001206166,0.0004877717,0.0001650748,0.00007472503,0.0003295489,0.0005786168,0.00002181918],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954319,0.0005222216,0.00005311941,0.00013797,0.00002413401,0.000007286065,0.002109099,0.000006391377,0.001707957],"genre_scores_gemma":[0.9962496,0.0001694283,0.00001959376,0.00006354319,0.00003755533,0.000007271148,0.002436251,0.000004865926,0.001011893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006881731,"threshold_uncertainty_score":0.0230217,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01569623952434319,"score_gpt":0.3154044142511861,"score_spread":0.2997081747268429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}