{"id":"W4387011773","doi":"10.1101/2023.09.25.558961","title":"Deacetylation by sirtuins is important for <i>Aspergillus fumigatus</i> pathogenesis and virulence","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovation Cluster (Canada)","funders":"National Institute of Allergy and Infectious Diseases; Laboratório Nacional de Biociências; National Institutes of Health; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Centro Nacional de Pesquisa em Energia e Materiais; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Virulence; Aspergillus fumigatus; Biology; Sirtuin; Acetylation; Histone; Gene; SIRT2; Microbiology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001352086,0.000309474,0.000246304,0.0001791046,0.0001838861,0.0004365046,0.0001398099,0.0002727427,0.001679173],"category_scores_gemma":[0.0001365381,0.0001310769,0.0003592631,0.0001691139,0.0001981339,0.0001560673,0.0002260741,0.0003939831,0.000665894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002968419,"about_ca_system_score_gemma":0.0001816849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001221741,"about_ca_topic_score_gemma":0.001483857,"domain_scores_codex":[0.9998604,0.00001770705,0.0000107145,0.00003656944,0.00004288051,0.00003160415],"domain_scores_gemma":[0.9999148,0.00000614104,0.0000344065,0.000010916,0.00001267631,0.00002107624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001269993,0.00001105572,0.001770224,0.0000454476,0.00001291568,0.00006794527,0.00001060714,0.00007758336,0.9949303,0.0001876786,0.0002775623,0.002481597],"study_design_scores_gemma":[0.00002376324,0.000139413,0.04920718,0.00001636961,0.00004714077,0.0006473331,0.0000726378,0.001552635,0.9356101,0.0003100272,0.01236158,0.00001180569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9745181,0.006095633,0.01028136,0.0006766653,0.0002085184,0.00002723064,0.002346412,0.0004391116,0.005407018],"genre_scores_gemma":[0.992623,0.001142695,0.002095545,0.00008631001,0.0000233833,0.000007725767,0.001324918,0.00003562601,0.002660776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001679173,"threshold_uncertainty_score":0.00561744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02078123345724959,"score_gpt":0.2504148883778697,"score_spread":0.2296336549206201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}