{"id":"W4387011968","doi":"10.1371/journal.ppat.1011658","title":"Choline metabolism underpins macrophage IL-4 polarization and RELMα up-regulation in helminth infection","year":2023,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Institute of Infection and Immunity; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; University of Ottawa","keywords":"Choline; Biology; Macrophage polarization; Immune system; Macrophage; Lipid metabolism; Metabolism; Heligmosomoides polygyrus; Cell biology; Biochemistry; Immunology; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001680656,0.0001555791,0.0001400636,0.0002642115,0.0001010241,0.00003058368,0.00005627298,0.0002473691,0.00003808692],"category_scores_gemma":[0.0001652455,0.0001616884,0.00004032952,0.000484864,0.00003722384,0.00001497787,0.0000728693,0.000123714,0.00006018994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003810756,"about_ca_system_score_gemma":0.00005789166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001278176,"about_ca_topic_score_gemma":0.0004114356,"domain_scores_codex":[0.9989569,0.00009905524,0.0001979131,0.0003546712,0.0001252687,0.0002662341],"domain_scores_gemma":[0.999563,0.000007885518,0.00006137948,0.0001976384,0.00006891919,0.0001011297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002478726,0.00003753105,0.03070344,0.00001565784,0.00002718235,0.000002109608,0.0000835406,0.0001225898,0.9672914,0.00003443179,0.00007839513,0.001578916],"study_design_scores_gemma":[0.0005176557,0.00005609555,0.1671898,0.00001441219,0.00002154599,0.0000070017,0.00002418659,0.001217367,0.8271431,0.00009734342,0.003516719,0.0001948114],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985789,0.0001706376,0.0003757878,0.0001247699,0.0002306652,0.0002398501,0.00007664145,0.00006156266,0.0001411808],"genre_scores_gemma":[0.9977711,0.0004610205,0.0001487179,0.0000979121,0.000196481,0.00003499992,0.0007657257,0.00003800938,0.0004860467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1401483,"threshold_uncertainty_score":0.6593463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01363750131762015,"score_gpt":0.2436702147585869,"score_spread":0.2300327134409667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}