{"id":"W4387012311","doi":"10.21203/rs.3.rs-3359209/v1","title":"Transmission of highly virulent CXCR4 tropic HIV-1 through the mucosal route in an individual with a wild-type CCR5 genotype","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"National Institutes of Health; Henry M. Jackson Foundation; U.S. Department of Health and Human Services; U.S. Department of Defense","keywords":"Virulence; Genotype; Transmission (telecommunications); Biology; Human immunodeficiency virus (HIV); Virology; CXCR4; Microbiology; Genetics; Gene; Computer science; Receptor; Telecommunications; Chemokine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001637969,0.0003692765,0.0002850531,0.0002502192,0.001053507,0.0004491202,0.0002214802,0.001021125,0.001717311],"category_scores_gemma":[0.0005389996,0.0001820742,0.000194158,0.0001137673,0.0002836618,0.0002639793,0.0002233714,0.0008009692,0.0002699909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000176823,"about_ca_system_score_gemma":0.000136845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003834015,"about_ca_topic_score_gemma":0.002108831,"domain_scores_codex":[0.9998822,0.00002246325,0.000006613983,0.00003605767,0.0000104183,0.00004236917],"domain_scores_gemma":[0.9998791,0.00003828753,0.00001935014,0.00001902959,0.000009810479,0.00003445808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"case_report","study_design_scores_codex":[0.008027093,0.005921325,0.4918802,0.0001671226,0.0002669512,0.2105721,0.01229988,0.001800686,0.2044309,0.005359603,0.008832102,0.0504421],"study_design_scores_gemma":[0.000273961,0.01231841,0.6831627,0.0001058242,0.0003141544,0.2503059,0.009752239,0.0122841,0.02395368,0.003189058,0.00419255,0.0001473211],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985141,0.00002699393,0.000218062,0.00009006199,0.00001842406,0.00001240863,0.0001036243,0.000007888435,0.001008376],"genre_scores_gemma":[0.9978966,0.00004139459,0.0004037917,0.0001028035,0.00001708864,0.000005172036,0.00006919032,0.000004555839,0.001459388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003834015,"threshold_uncertainty_score":0.007623374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08509149067569091,"score_gpt":0.3740275093062158,"score_spread":0.2889360186305249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}