{"id":"W4387013888","doi":"10.1038/s43587-023-00490-2","title":"APOEε4 potentiates amyloid β effects on longitudinal tau pathology","year":2023,"lang":"en","type":"article","venue":"Nature Aging","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital; University of Toronto; Sunnybrook Health Science Centre; Artificial Intelligence in Medicine (Canada); McGill University; Douglas Mental Health University Institute","funders":"National Institute on Aging; Fonds de Recherche du Québec - Santé; HORIZON EUROPE Framework Programme; National Institutes of Health; Instituto Serrapilheira; UK Dementia Research Institute; Vetenskapsrådet; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Familjen Erling-Perssons Stiftelse; Fondation Brain Canada; European Commission; Hjärnfonden; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Cerveau Technologies; EU Joint Programme – Neurodegenerative Disease Research; Alzheimer's Association; Stiftelsen för Gamla Tjänarinnor; McGill University; BrightFocus Foundation; Consortium canadien en neurodégénérescence associée au vieillissement; Canadian Institutes of Health Research; Alzheimerfonden; Weston Brain Institute; Alzheimer's Drug Discovery Foundation","keywords":"Apolipoprotein E; Pittsburgh compound B; Positron emission tomography; Amyloid (mycology); Medicine; Alzheimer's Disease Neuroimaging Initiative; Magnetic resonance imaging; Pathology; Internal medicine; Longitudinal study; Pathophysiology; Postmortem studies; Alzheimer's disease; Endocrinology; Psychology; Oncology; Disease; Nuclear medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001319796,0.0001588698,0.0002179696,0.0002560084,0.0001274712,0.00002058399,0.00007694933,0.0001730383,0.0000481295],"category_scores_gemma":[0.0001264754,0.000120465,0.0001151945,0.000418002,0.00004004823,0.00005055587,0.00006211254,0.0006103719,0.0007765896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005631528,"about_ca_system_score_gemma":0.00005814585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001119501,"about_ca_topic_score_gemma":0.000002726356,"domain_scores_codex":[0.9986387,0.0000555258,0.00009516751,0.0003450079,0.0003911431,0.0004744302],"domain_scores_gemma":[0.9992442,0.0001650869,0.00002895448,0.000266679,0.00006233586,0.0002327934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000797934,0.0005995817,0.8818324,0.0005296064,0.006442104,0.0438097,0.0001954548,0.00001771547,0.002649776,0.0006367902,0.02499261,0.03749638],"study_design_scores_gemma":[0.002264971,0.0003846871,0.9860337,0.0002513826,0.0003207138,0.0001363052,0.0000354673,0.000151465,0.009183354,0.000589643,0.0005010404,0.0001472821],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862015,0.008310053,0.000009031434,0.002497123,0.0003145333,0.000374057,0.00001138623,0.0002944407,0.00198788],"genre_scores_gemma":[0.9984195,0.0001381401,0.00005404119,0.0006270147,0.0003127336,0.00003448804,0.0001488866,0.00002902425,0.0002361518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1042013,"threshold_uncertainty_score":0.9981747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01553925488339548,"score_gpt":0.3288775989076299,"score_spread":0.3133383440242344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}