{"id":"W4387013888","doi":"10.1038/s43587-023-00490-2","title":"APOEε4 potentiates amyloid β effects on longitudinal tau pathology","year":2023,"lang":"en","type":"article","venue":"Nature Aging","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital; University of Toronto; Sunnybrook Health Science Centre; Artificial Intelligence in Medicine (Canada); McGill University; Douglas Mental Health University Institute","funders":"National Institute on Aging; Fonds de Recherche du Québec - Santé; HORIZON EUROPE Framework Programme; National Institutes of Health; Instituto Serrapilheira; UK Dementia Research Institute; Vetenskapsrådet; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Familjen Erling-Perssons Stiftelse; Fondation Brain Canada; European Commission; Hjärnfonden; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Cerveau Technologies; EU Joint Programme – Neurodegenerative Disease Research; Alzheimer's Association; Stiftelsen för Gamla Tjänarinnor; McGill University; BrightFocus Foundation; Consortium canadien en neurodégénérescence associée au vieillissement; Canadian Institutes of Health Research; Alzheimerfonden; Weston Brain Institute; Alzheimer's Drug Discovery Foundation","keywords":"Apolipoprotein E; Pittsburgh compound B; Positron emission tomography; Amyloid (mycology); Medicine; Alzheimer's Disease Neuroimaging Initiative; Magnetic resonance imaging; Pathology; Internal medicine; Longitudinal study; Pathophysiology; Postmortem studies; Alzheimer's disease; Endocrinology; Psychology; Oncology; Disease; Nuclear medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004912129,0.0006611282,0.0005687081,0.00045838,0.0002221383,0.0004734335,0.0005639131,0.0005852858,0.004139256],"category_scores_gemma":[0.0008040085,0.0004631816,0.0005936077,0.0001958967,0.0005257246,0.0004770189,0.0004988113,0.0008036604,0.0007209153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002936303,"about_ca_system_score_gemma":0.0005189731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00152691,"about_ca_topic_score_gemma":0.001684131,"domain_scores_codex":[0.9997582,0.00005667459,0.00002608594,0.00003435253,0.0000286592,0.00009608766],"domain_scores_gemma":[0.9994656,0.00007791628,0.0001230629,0.00008949808,0.00006113399,0.0001827421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01718484,0.0007509567,0.001116894,0.00009780237,0.00009074245,0.0003174081,0.00005567103,0.0001327751,0.9743996,0.000197154,0.0001676764,0.005488519],"study_design_scores_gemma":[0.001115284,0.01270131,0.05501867,0.00006509909,0.0003106764,0.001167122,0.0002451394,0.0009841643,0.9246203,0.0009182286,0.002809714,0.00004440384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978771,0.0005486557,0.0003918996,0.0001129573,0.00006825305,0.00001487285,0.0001380232,0.00005142438,0.0007967997],"genre_scores_gemma":[0.993016,0.0008355212,0.0005909113,0.0001074938,0.00004749734,0.00002960584,0.0002090439,0.00004464559,0.005119372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004139256,"threshold_uncertainty_score":0.01384717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01553925488339548,"score_gpt":0.3288775989076299,"score_spread":0.3133383440242344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}