{"id":"W4387014784","doi":"10.1016/j.jaad.2023.07.241","title":"43335 Ixekizumab reduces IL-17 and IL-23 pathway genes more rapidly than guselkumab: 4-week results from IXORA-R","year":2023,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Probity Medical Research","funders":"","keywords":"Ixekizumab; Medicine; Psoriasis; Interleukin 17; Plaque psoriasis; Interleukin 23; Blockade; Dermatology; Immunology; Internal medicine; Secukinumab; Cytokine; Psoriatic arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005038862,0.0007056369,0.001063141,0.000238866,0.0002616068,0.0007310281,0.0003988531,0.0007076501,0.004384771],"category_scores_gemma":[0.0002687479,0.0002474798,0.001231479,0.000132709,0.0004205375,0.0004533559,0.0001693634,0.002676593,0.001159726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000383834,"about_ca_system_score_gemma":0.0007711712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001139341,"about_ca_topic_score_gemma":0.001452406,"domain_scores_codex":[0.9996392,0.00007551847,0.00002396933,0.00005346091,0.00004913827,0.0001588648],"domain_scores_gemma":[0.9998362,0.00002542629,0.0000256676,0.00003077267,0.00001407082,0.00006792769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.1095622,0.02370847,0.001615432,0.0004530463,0.0004479226,0.0002596898,0.0001457855,0.001144535,0.763561,0.0003531661,0.005900549,0.09284837],"study_design_scores_gemma":[0.03838673,0.3675596,0.04259961,0.00007387502,0.001172743,0.001228137,0.0003340124,0.003843922,0.525432,0.0005059691,0.0187513,0.0001121922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994094,0.001937615,0.0007333109,0.0004208142,0.000291339,0.00016281,0.0006698027,0.0001919672,0.001498552],"genre_scores_gemma":[0.9895335,0.001275517,0.001222534,0.0002800518,0.0001375168,0.0001559673,0.001588089,0.00006498881,0.005741775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004384771,"threshold_uncertainty_score":0.01466858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02499767763871115,"score_gpt":0.2703099281402654,"score_spread":0.2453122505015543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}