{"id":"W4387015096","doi":"10.1016/j.jaad.2023.07.145","title":"43887 Deucravacitinib, an Oral, Selective, Allosteric Tyrosine Kinase 2 Inhibitor, in Moderate to Severe Plaque Psoriasis: Efficacy by Baseline Demographic and Disease Characteristics in the Phase 3 POETYK PSO-1 and PSO-2 Trials","year":2023,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Probity Medical Research; Queen's University","funders":"","keywords":"Medicine; Plaque psoriasis; Placebo; Psoriasis; Apremilast; Internal medicine; Pharmacology; Clinical trial; Dermatology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006858122,0.000596726,0.001418534,0.0002249646,0.0002241636,0.0006328159,0.0003298347,0.0004813271,0.003174193],"category_scores_gemma":[0.0003665584,0.000209487,0.0007643452,0.0002432815,0.0002321968,0.0004072024,0.0001647422,0.001265238,0.0006175711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004692336,"about_ca_system_score_gemma":0.0004896748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007797866,"about_ca_topic_score_gemma":0.003668852,"domain_scores_codex":[0.9998096,0.00006556547,0.00001149801,0.0000286113,0.00003315928,0.0000517622],"domain_scores_gemma":[0.9998307,0.00003607345,0.00003047444,0.000009352829,0.00001644573,0.00007686047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3469667,0.01032137,0.01416352,0.001929973,0.002287849,0.0002342213,0.0001628885,0.00326745,0.04355371,0.0007208107,0.02020187,0.5561897],"study_design_scores_gemma":[0.5288838,0.2721271,0.1361745,0.000312115,0.002150431,0.002087896,0.0002015304,0.008900234,0.01294825,0.001157094,0.03488257,0.0001745537],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9736726,0.01695473,0.0004918927,0.0005719349,0.0001626079,0.0004266758,0.001224294,0.0003250909,0.006170044],"genre_scores_gemma":[0.9885837,0.004665676,0.0006544787,0.0004679977,0.00009681616,0.0002500481,0.001815079,0.00002714431,0.003439056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003174193,"threshold_uncertainty_score":0.01061869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03090981902972537,"score_gpt":0.3194996324755663,"score_spread":0.288589813445841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}