{"id":"W4387015875","doi":"10.1016/j.jaad.2023.07.491","title":"42163 Apremilast in Pediatric Patients With Moderate to Severe Plaque Psoriasis: 16-Week Efficacy and Safety Results From the Phase 3, Randomized, Double-Blind, Placebo-Controlled SPROUT Study","year":2023,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Stollery Children's Hospital; University of Alberta","funders":"","keywords":"Medicine; Apremilast; Psoriasis; Plaque psoriasis; Dermatology; Placebo; Randomized controlled trial; Internal medicine; Psoriatic arthritis; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001277457,0.001242446,0.003038102,0.000280972,0.0002989506,0.0006420332,0.0006235847,0.001279863,0.00290144],"category_scores_gemma":[0.0007972897,0.0005705549,0.001339842,0.0002757625,0.0006805721,0.0007164232,0.0002593923,0.00243058,0.0006564244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002977543,"about_ca_system_score_gemma":0.0008220878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005028464,"about_ca_topic_score_gemma":0.001179445,"domain_scores_codex":[0.9995958,0.0002058996,0.00002729164,0.00006222519,0.00005281286,0.00005602551],"domain_scores_gemma":[0.9994259,0.0001537967,0.0001542813,0.00004320316,0.00003905619,0.0001837827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8476206,0.02349725,0.002677753,0.001835933,0.001674233,0.0003601622,0.0001739499,0.0009916102,0.02976593,0.0001949708,0.002347415,0.08886026],"study_design_scores_gemma":[0.7997507,0.1879715,0.008070415,0.00005914061,0.0004435341,0.0002838233,0.00004318076,0.0004860881,0.001842805,0.00009118643,0.0009361345,0.00002144194],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907327,0.005832849,0.0005241027,0.0002954592,0.0001527034,0.0008244919,0.0005457316,0.000170052,0.0009219511],"genre_scores_gemma":[0.9859468,0.00654409,0.001892405,0.0008714181,0.0003446672,0.001275946,0.0009106797,0.00005660735,0.002157509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003038102,"threshold_uncertainty_score":0.009706259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02033938590694062,"score_gpt":0.2796052257665601,"score_spread":0.2592658398596194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}