{"id":"W4387016064","doi":"10.1016/j.jaad.2023.07.628","title":"43516 Efficacy and Safety of Sonic Hedgehog Inhibitors in Basal Cell Carcinomas: An Updated Systematic Review and Meta-Analysis","year":2023,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Bispebjerg Hospital; Feinberg School of Medicine; University of California, San Diego; School of Medicine, University of California, San Diego; Northwestern University; AbbVie","keywords":"Medicine; Basal cell carcinoma; Meta-analysis; Skin cancer; Systematic review; Basal cell; Dermatology; Oncology; Clinical trial; Vismodegib; Internal medicine; MEDLINE; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005419348,0.00135491,0.01061883,0.002322851,0.0003104267,0.00203254,0.001390617,0.00154855,0.003916207],"category_scores_gemma":[0.01205406,0.0009650854,0.02098483,0.003756714,0.0006094464,0.001494136,0.001102613,0.001388429,0.0004152762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001043003,"about_ca_system_score_gemma":0.001458944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003382214,"about_ca_topic_score_gemma":0.01009147,"domain_scores_codex":[0.9956735,0.001411938,0.001495251,0.0007426762,0.0004658554,0.0002106966],"domain_scores_gemma":[0.9932204,0.003949176,0.00181531,0.0003599005,0.0005255235,0.0001295186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.006529321,0.00003786429,0.01362843,0.2246529,0.7349033,0.0001535711,0.0001100726,0.0005003319,0.0008321764,0.0001250482,0.001420256,0.0171067],"study_design_scores_gemma":[0.001811907,0.0002734658,0.01000599,0.006577368,0.9788637,0.00008706374,0.00004480145,0.00009070844,0.0001221312,0.0001236002,0.001969822,0.00002947485],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02111044,0.9749211,0.0006254495,0.0002935402,0.0002566226,0.0001740731,0.002031989,0.00003342644,0.000553398],"genre_scores_gemma":[0.5213119,0.4695322,0.001637124,0.002887114,0.0005140224,0.000489464,0.002626681,0.00006279603,0.0009386576],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01061883,"threshold_uncertainty_score":0.0286606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02651159787758799,"score_gpt":0.3057151947225278,"score_spread":0.2792035968449398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}