{"id":"W4387020481","doi":"10.20944/preprints202309.1566.v1","title":"CYP2D6 and CYP2C19 Variant Coverage of Commercial Antidepressant Pharmacogenomic Testing Panels Available in Victoria, Australia","year":2023,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Pharmacogenomics; CYP2C19; Genetic testing; CYP2D6; Selection (genetic algorithm); Dosing; Allele; Pharmacogenetics; Standardization; Medicine; Genetics; Biology; Computer science; Genotype; Pharmacology; Gene; Machine learning","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001957069,0.0001203486,0.0002045838,0.0007486102,0.0004342822,0.0007840862,0.0003290946,0.0002293682,0.001699377],"category_scores_gemma":[0.009549075,0.0002522952,0.000210981,0.001086235,0.0003656271,0.0003776417,0.00107061,0.0004008625,0.000211341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001441137,"about_ca_system_score_gemma":0.001936687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.1600007,"about_ca_topic_score_gemma":0.214448,"domain_scores_codex":[0.9977459,0.000660064,0.0002366564,0.0005376306,0.0005761959,0.0002435271],"domain_scores_gemma":[0.9967338,0.0008550206,0.000916656,0.0002130085,0.0008797419,0.0004018013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001662825,0.0000317726,0.936713,0.0001623362,0.00008605455,0.0005902579,0.00453384,0.0004116367,0.00389812,0.0005258937,0.002797775,0.05008303],"study_design_scores_gemma":[0.000004752686,0.00005335586,0.9925786,0.00008904596,0.00003435844,0.0008846561,0.0009285318,0.0006793776,0.0004226961,0.0001613249,0.004150665,0.00001270338],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934366,0.0008651307,0.0005850711,0.0004412993,0.00000874071,0.00002594135,0.001432389,0.00001385194,0.003190996],"genre_scores_gemma":[0.9974799,0.0002626315,0.0008272027,0.000150375,0.000004043404,0.00001138716,0.0005885745,0.00001201864,0.0006640036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1600007,"threshold_uncertainty_score":0.3181388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4911112998570809,"score_gpt":0.4841031189869471,"score_spread":0.007008180870133773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}