{"id":"W4387026281","doi":"10.1016/j.jaad.2023.07.759","title":"42134 Long-term Efficacy of Guselkumab (GUS) on Fatigue and Identification of Early Treatment Targets: Post Hoc Analysis Through 2 Years of a Phase 3, Randomized, Double-blind, Placebo-controlled Study in Biologic-naïve Patients With Psoriatic Arthritis (PsA)","year":2023,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; GDI Integrated Facility Services (Canada); Montreal General Hospital; Krembil Foundation; Toronto Western Hospital","funders":"","keywords":"Medicine; Post-hoc analysis; Placebo; Double blind; Post hoc; Term (time); Internal medicine; Oncology; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002322651,0.001347023,0.003851893,0.0004563686,0.0005622797,0.0008548293,0.000738444,0.001548089,0.003917699],"category_scores_gemma":[0.001351349,0.0007461011,0.002902015,0.0004958835,0.001269138,0.001043753,0.0004454241,0.002778699,0.0006500246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005161579,"about_ca_system_score_gemma":0.001011789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009956349,"about_ca_topic_score_gemma":0.002142418,"domain_scores_codex":[0.9989482,0.0005477424,0.00006206668,0.0001605692,0.00007531981,0.0002062925],"domain_scores_gemma":[0.9990041,0.000299729,0.0001760635,0.0001228932,0.00007882027,0.0003184996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9715125,0.007525724,0.000998926,0.0002267086,0.001076003,0.00002316531,0.00003514952,0.0003287763,0.006536567,0.00002958467,0.0002179327,0.01148884],"study_design_scores_gemma":[0.5998934,0.3806826,0.01465604,0.00002483343,0.00153251,0.000036809,0.00003914048,0.0005730345,0.001906178,0.00008301921,0.0005408091,0.0000316361],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954561,0.002218169,0.0003428437,0.0001362162,0.0001261717,0.0006058501,0.00050966,0.00006888447,0.0005361764],"genre_scores_gemma":[0.9950613,0.001026613,0.0006274503,0.0002649883,0.000203215,0.0007792903,0.0007356767,0.00002263602,0.00127881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003917699,"threshold_uncertainty_score":0.01310599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02617833358952999,"score_gpt":0.3171300572902101,"score_spread":0.2909517237006801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}