{"id":"W4387026325","doi":"10.1016/j.jaad.2023.07.730","title":"43117 Integrated safety analysis of ritlecitinib in adolescent patients with alopecia areata from the randomized, placebo-controlled ALLEGRO phase 2b/3 and ongoing open-label phase 3 ALLEGRO-LT studies","year":2023,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Probity Medical Research","funders":"","keywords":"Alopecia areata; Medicine; Placebo; Hair loss; Open label; Dermatology; Randomized controlled trial; Internal medicine; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007933028,0.0002337646,0.003014183,0.0005356529,0.0001006496,0.00001445834,0.0004468611,0.00006365918,0.00004110656],"category_scores_gemma":[0.001256032,0.0001117401,0.000323107,0.001262727,0.0007776261,0.0001245669,0.0001949765,0.000704658,8.785298e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000655605,"about_ca_system_score_gemma":0.0001251752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001523784,"about_ca_topic_score_gemma":0.0000872892,"domain_scores_codex":[0.9968092,0.0008215599,0.00154537,0.0002102396,0.0003776684,0.000235997],"domain_scores_gemma":[0.9949651,0.002302841,0.002184485,0.0002056602,0.0002491184,0.00009279595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8821151,0.004231923,0.04444631,0.00007182632,0.03135923,0.0001373323,0.003209042,0.000395111,0.01135586,0.000175965,0.01159739,0.0109049],"study_design_scores_gemma":[0.9372049,0.001025279,0.02867678,0.001553689,0.01021511,0.00025868,0.005958285,0.00746636,0.003328714,0.00008564053,0.003958952,0.0002676348],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878255,0.0007995808,0.00017506,0.009968645,0.00007397319,0.0008836167,0.0002142144,0.000007387037,0.00005209132],"genre_scores_gemma":[0.9967096,0.001610632,0.0004031005,0.00114747,0.00004191646,0.00001968019,0.00002976501,0.00001830931,0.00001945871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05508977,"threshold_uncertainty_score":0.4556631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05473817354729585,"score_gpt":0.3909709963074463,"score_spread":0.3362328227601504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}