{"id":"W4387026325","doi":"10.1016/j.jaad.2023.07.730","title":"43117 Integrated safety analysis of ritlecitinib in adolescent patients with alopecia areata from the randomized, placebo-controlled ALLEGRO phase 2b/3 and ongoing open-label phase 3 ALLEGRO-LT studies","year":2023,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Probity Medical Research","funders":"","keywords":"Alopecia areata; Medicine; Placebo; Hair loss; Open label; Dermatology; Randomized controlled trial; Internal medicine; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002121223,0.0005023765,0.001492923,0.0003250132,0.000283565,0.0008562673,0.0004291287,0.0007805452,0.004702617],"category_scores_gemma":[0.001451285,0.0002420315,0.002051646,0.0003079808,0.0003731701,0.0005762557,0.0002072362,0.002057066,0.0006561574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006712468,"about_ca_system_score_gemma":0.0009976047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000481793,"about_ca_topic_score_gemma":0.00172061,"domain_scores_codex":[0.9991832,0.0004325217,0.00005103727,0.00009804647,0.0001259165,0.0001092641],"domain_scores_gemma":[0.9990627,0.0003055359,0.0002694576,0.00007786943,0.0001139492,0.0001705325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5831802,0.007659225,0.01551136,0.002603466,0.00664279,0.0002179142,0.0001672098,0.002535146,0.02235381,0.0006237057,0.008266727,0.3502383],"study_design_scores_gemma":[0.6334682,0.252843,0.07454634,0.0004081636,0.006321596,0.0009015734,0.0001145115,0.002723329,0.007599363,0.0006606954,0.02031799,0.00009529391],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9708896,0.01637833,0.00143465,0.0008757284,0.0002211274,0.001594695,0.003493692,0.0002103695,0.004901745],"genre_scores_gemma":[0.9871268,0.00420862,0.001488503,0.001087628,0.0002127733,0.0008690799,0.003172814,0.00003556751,0.00179826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004702617,"threshold_uncertainty_score":0.01573187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05473817354729585,"score_gpt":0.3909709963074463,"score_spread":0.3362328227601504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}