{"id":"W4387032905","doi":"10.1002/jmv.29113","title":"The binding profile of SARS‐CoV‐2 with human leukocyte antigen polymorphisms reveals critical alleles involved in immune evasion","year":2023,"lang":"en","type":"article","venue":"Journal of Medical Virology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Xiangya Hospital, Central South University; Central South University; National Natural Science Foundation of China","keywords":"Immune system; Human leukocyte antigen; Biology; Virology; Immunology; Allele; Antigen; Evasion (ethics); Antibody; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001581865,0.000257523,0.000233336,0.0002257855,0.0001516386,0.0001984277,0.0001246843,0.0002329176,0.002279222],"category_scores_gemma":[0.0002796951,0.0001125756,0.0002549104,0.0001909821,0.0001062471,0.0001259286,0.0001332368,0.0002999696,0.0003468848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001562646,"about_ca_system_score_gemma":0.0001118869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001423806,"about_ca_topic_score_gemma":0.001397807,"domain_scores_codex":[0.9998504,0.00003409757,0.00000936374,0.00002609676,0.00003443484,0.00004554673],"domain_scores_gemma":[0.9998732,0.00003495587,0.00002786601,0.00000842782,0.00001946836,0.00003609054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005541058,0.0001413856,0.06554823,0.00004893991,0.00006468051,0.0003384382,0.00009096022,0.001017468,0.9274622,0.0003378567,0.0002514773,0.004144249],"study_design_scores_gemma":[0.00006144421,0.001282611,0.6055349,0.00002674665,0.0001447484,0.002771658,0.0004580729,0.02565498,0.3591263,0.0006883785,0.004186421,0.00006384186],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989114,0.0001740757,0.00040563,0.00001892247,0.000004120723,0.000003024135,0.00007190929,0.000004339349,0.0004065864],"genre_scores_gemma":[0.9993322,0.00003962287,0.0002419697,0.00002968963,0.000001999239,0.000001612209,0.0001133433,0.000002557714,0.0002367788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002279222,"threshold_uncertainty_score":0.007624745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07912582544582417,"score_gpt":0.4061090545614635,"score_spread":0.3269832291156393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}