{"id":"W4387032905","doi":"10.1002/jmv.29113","title":"The binding profile of SARS‐CoV‐2 with human leukocyte antigen polymorphisms reveals critical alleles involved in immune evasion","year":2023,"lang":"en","type":"article","venue":"Journal of Medical Virology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Xiangya Hospital, Central South University; Central South University; National Natural Science Foundation of China","keywords":"Immune system; Human leukocyte antigen; Biology; Virology; Immunology; Allele; Antigen; Evasion (ethics); Antibody; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00452217,0.0001520568,0.0006994671,0.0005070061,0.0001331793,0.00001506284,0.0005086385,0.0003291417,0.00005110253],"category_scores_gemma":[0.003082333,0.00008571823,0.0001526016,0.0005694602,0.0008615838,0.00007444555,0.0001777478,0.001187927,0.00003163916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008932561,"about_ca_system_score_gemma":0.0006740746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001042669,"about_ca_topic_score_gemma":0.000105173,"domain_scores_codex":[0.9961832,0.0004112448,0.0009866158,0.0001957382,0.001666164,0.0005570954],"domain_scores_gemma":[0.9979508,0.001198041,0.0002626993,0.0002684747,0.0002064034,0.0001136099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002192315,0.0002456359,0.05986221,0.0001066648,0.0001359731,0.002466306,0.0002666919,2.517734e-7,0.9296438,0.0006555436,0.001907387,0.002517271],"study_design_scores_gemma":[0.01453457,0.00931352,0.4123152,0.002245178,0.0001825505,0.002024271,0.001551999,0.0009708166,0.5307447,0.002683287,0.02307539,0.0003584978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804053,0.001483732,0.00005202849,0.01749928,0.0001657929,0.0002012446,0.000001585235,0.00001608786,0.00017494],"genre_scores_gemma":[0.9947209,0.0002519952,0.00009457344,0.004592541,0.0002805386,0.00001018732,0.000002251553,0.00002495247,0.00002208017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.398899,"threshold_uncertainty_score":0.5161018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07912582544582417,"score_gpt":0.4061090545614635,"score_spread":0.3269832291156393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}