{"id":"W4387033134","doi":"10.1172/jci169200","title":"The catalytic subunit of DNA-PK regulates transcription and splicing of AR in advanced prostate cancer","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Genentech; Sierra Oncology; Astellas Pharma; Eisai; Newcastle University; Prostate Cancer UK; National Institute for Health and Care Research; Wellcome Trust; JGW Patterson Foundation; Prostate Cancer Foundation; Movember Foundation; AstraZeneca; Pfizer; Amgen; Sanofi; Cancer Research UK; Vertex Pharmaceuticals","keywords":"Prostate cancer; Androgen receptor; RNA splicing; Signalling; Cancer research; Protein subunit; Alternative splicing; Function (biology); Prostate; Receptor; Medicine; Cancer; Cell biology; Chemistry; Biology; Computational biology; Internal medicine; Genetics; Gene isoform; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001073184,0.0002151245,0.0001462212,0.0001856933,0.0001541272,0.0004007644,0.000169893,0.0002219002,0.001466956],"category_scores_gemma":[0.0001719722,0.0001246722,0.0001542624,0.0001297076,0.0002694457,0.0002231451,0.0001517549,0.0005885967,0.0005304506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004914494,"about_ca_system_score_gemma":0.0003574334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004604793,"about_ca_topic_score_gemma":0.0005345148,"domain_scores_codex":[0.9998752,0.00001554647,0.000008001307,0.00003725415,0.00003988201,0.00002403809],"domain_scores_gemma":[0.9999161,0.00001047461,0.00002918609,0.000007738657,0.00001111856,0.00002538315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002260852,0.00004418982,0.001373915,0.00006398536,0.000005636888,0.00008497883,0.00002445183,0.0002629441,0.9913946,0.0005592323,0.00007739521,0.005882529],"study_design_scores_gemma":[0.00004866512,0.0005773786,0.03001776,0.00001386998,0.00002086675,0.001036844,0.00007761121,0.002094029,0.9558988,0.0006616144,0.009540862,0.00001172997],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792443,0.01069196,0.006073056,0.0003693081,0.00007830389,0.00004118918,0.000309728,0.0001409877,0.003051154],"genre_scores_gemma":[0.9956117,0.001819868,0.0008135587,0.00002597602,0.000010443,0.0000110609,0.0001796257,0.000007660905,0.001520119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001466956,"threshold_uncertainty_score":0.004907489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1027417939017365,"score_gpt":0.4265792814233448,"score_spread":0.3238374875216083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}