{"id":"W4387033262","doi":"10.1128/spectrum.01904-23","title":"Proteasome inhibition as a therapeutic target for the fungal pathogen <i>Cryptococcus neoformans</i>","year":2023,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; University of California, San Francisco; Conselho Nacional de Desenvolvimento Científico e Tecnológico; National Institutes of Health; Yonsei University; Government of Canada; Canadian Institute for Advanced Research","keywords":"Cryptococcus neoformans; Fungal pathogen; Pathogen; Microbiology; Cryptococcosis; Cryptococcus; Biology; Proteasome; Antifungal; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001638794,0.0004902672,0.0003518702,0.0001992426,0.0001685886,0.0003784773,0.0002286608,0.0003007525,0.001008042],"category_scores_gemma":[0.00005739312,0.00008642132,0.0002746434,0.0001478802,0.0002202715,0.0001276335,0.0001189765,0.0006328168,0.0002419305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005450023,"about_ca_system_score_gemma":0.0003475106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001505603,"about_ca_topic_score_gemma":0.00281405,"domain_scores_codex":[0.999881,0.00001732355,0.000008673286,0.00002014074,0.00003294491,0.00003994615],"domain_scores_gemma":[0.9999524,0.000005212567,0.00001787354,0.000004144832,0.000007208072,0.00001315568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003260339,0.0001246489,0.0003985465,0.0001161014,0.00001279821,0.0001543283,0.00000620726,0.0002792961,0.990639,0.0001561952,0.0003637105,0.007423159],"study_design_scores_gemma":[0.00007626791,0.001571047,0.003048841,0.00001767418,0.00003457292,0.0008440982,0.00001495327,0.0007179437,0.9878618,0.00006035084,0.005745292,0.000007071703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9669396,0.02032303,0.003607463,0.001199697,0.0002026225,0.0001540072,0.0007729221,0.000225046,0.006575626],"genre_scores_gemma":[0.9905054,0.004145987,0.003113128,0.0002474338,0.00003151248,0.0000284893,0.0003189584,0.00001612696,0.001592924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001505603,"threshold_uncertainty_score":0.003954232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01751435740643742,"score_gpt":0.271723653139561,"score_spread":0.2542092957331236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}