{"id":"W4387033429","doi":"10.1002/cbic.202300594","title":"Double Stranded DNA Binding Stapled Peptides: An Emerging Tool for Transcriptional Regulation","year":2023,"lang":"en","type":"review","venue":"ChemBioChem","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"DNA; Peptide; Biology; HMG-box; Biochemistry; DNA-binding protein; Computational biology; Binding site; Binding selectivity; Protein–DNA interaction; Chemistry; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002810211,0.0006128594,0.0007228939,0.001106752,0.0001707497,0.0006070284,0.0005557466,0.000817916,0.002248811],"category_scores_gemma":[0.0002415872,0.0002917398,0.0003270607,0.00114071,0.0003798365,0.0009293442,0.0003947887,0.001433581,0.00184774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004095999,"about_ca_system_score_gemma":0.0003918664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002712459,"about_ca_topic_score_gemma":0.0004140926,"domain_scores_codex":[0.9998679,0.00001574618,0.00001016119,0.00002569975,0.00006307122,0.0000174845],"domain_scores_gemma":[0.999895,0.00004860608,0.00001991653,0.000003644771,0.00002086992,0.00001202493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009868411,0.000121896,0.0001467976,0.01844051,0.00007168474,0.0003316326,0.00006659303,0.00109442,0.06580267,0.01473833,0.01404418,0.8850427],"study_design_scores_gemma":[0.00001448275,0.0002048965,0.0003830962,0.0008372795,0.00003952138,0.0008228479,0.00002796041,0.0002413451,0.01436851,0.002187632,0.9808503,0.00002213024],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009975701,0.994083,0.001469387,0.0002184699,0.0003090745,0.00001094964,0.000040927,0.00002969474,0.002840956],"genre_scores_gemma":[0.00462649,0.9913868,0.001344577,0.0002882989,0.0001592475,0.00001946555,0.00006409908,0.000005034124,0.002105957],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002248811,"threshold_uncertainty_score":0.00752306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08993025740254407,"score_gpt":0.3599706703123587,"score_spread":0.2700404129098146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}