{"id":"W4387033429","doi":"10.1002/cbic.202300594","title":"Double Stranded DNA Binding Stapled Peptides: An Emerging Tool for Transcriptional Regulation","year":2023,"lang":"en","type":"review","venue":"ChemBioChem","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"DNA; Peptide; Biology; HMG-box; Biochemistry; DNA-binding protein; Computational biology; Binding site; Binding selectivity; Protein–DNA interaction; Chemistry; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003667088,0.0004698967,0.0009557228,0.0001145003,0.0001527729,0.00008729732,0.0003564659,0.0005834491,0.00008445187],"category_scores_gemma":[0.00006841039,0.000435547,0.001160825,0.000284068,0.00005281802,0.000009114076,0.00005621383,0.0001416355,0.00002404153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006540499,"about_ca_system_score_gemma":0.0001475976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004346874,"about_ca_topic_score_gemma":0.000009050873,"domain_scores_codex":[0.9978112,0.00003489967,0.000672568,0.0008702509,0.0001967705,0.0004143025],"domain_scores_gemma":[0.9989374,0.0000424628,0.0002801398,0.0005113131,0.0001003063,0.0001283713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001075919,0.0001455927,0.000002235016,0.0091032,0.001012694,0.000001138014,0.00003668164,0.000003717028,0.7766384,0.0001332592,0.002009718,0.2108057],"study_design_scores_gemma":[0.0006489614,0.00004718715,0.000001288714,0.001197073,0.0008386071,0.000004298687,0.00003361178,0.00002857632,0.3517174,0.00005280753,0.6448319,0.0005982665],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04429846,0.9518013,0.0009656567,0.00005295714,0.0002438894,0.001552025,0.0006174506,0.0001487787,0.0003194757],"genre_scores_gemma":[0.003975456,0.9723241,0.0006130945,0.00001918551,0.001293363,0.0005041286,0.01595249,0.0001917197,0.005126444],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6428221,"threshold_uncertainty_score":0.9998096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08993025740254407,"score_gpt":0.3599706703123587,"score_spread":0.2700404129098146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}