{"id":"W4387034114","doi":"10.1186/s41181-023-00208-0","title":"[225Ac]Ac- and [111In]In-DOTA-trastuzumab theranostic pair: cellular dosimetry and cytotoxicity in vitro and tumour and normal tissue uptake in vivo in NRG mice with HER2-positive human breast cancer xenografts","year":2023,"lang":"en","type":"article","venue":"EJNMMI Radiopharmacy and Chemistry","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"Leslie Dan Faculty of Pharmacy, University of Toronto; University of Toronto; Canadian Institutes of Health Research; Terry Fox Foundation","keywords":"Trastuzumab; DOTA; Radioimmunotherapy; In vivo; Cytotoxicity; In vitro; Medicine; Breast cancer; Pharmacology; Cancer research; Chemistry; Cancer; Internal medicine; Immunology; Monoclonal antibody; Antibody; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004197499,0.000327236,0.0003074865,0.0002240217,0.0001080074,0.0002078855,0.0002615339,0.0003049175,0.0004477303],"category_scores_gemma":[0.0001381708,0.0001845393,0.0001380009,0.0001856342,0.0002328295,0.0001425637,0.00009673599,0.0003442481,0.0001880526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004244666,"about_ca_system_score_gemma":0.0001972262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002083367,"about_ca_topic_score_gemma":0.001163088,"domain_scores_codex":[0.9997039,0.00007758802,0.00002050462,0.00007375784,0.00007862863,0.00004554279],"domain_scores_gemma":[0.9998935,0.00002161293,0.00002916356,0.00001570318,0.00001859516,0.00002134542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002367233,0.00006783418,0.0001792725,0.00001720137,0.000006666788,0.00001792634,0.00002447953,0.0004319553,0.9981142,0.00006840502,0.00002857633,0.0008066856],"study_design_scores_gemma":[0.00001478995,0.0008401365,0.00106961,0.000001438181,0.00001741354,0.0000592685,0.00001070059,0.002226801,0.9952908,0.00001270187,0.0004522228,0.000004063475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946814,0.000600535,0.003277428,0.000036652,0.00001181327,0.00004374213,0.0001476707,0.00006356047,0.001137097],"genre_scores_gemma":[0.9900419,0.0003408168,0.006066655,0.00002110366,0.000005910971,0.00005113678,0.0002716806,0.00002229335,0.003178431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002083367,"threshold_uncertainty_score":0.004142463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009951101079777484,"score_gpt":0.2845354501646619,"score_spread":0.2745843490848844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}