{"id":"W4387036061","doi":"10.20944/preprints202309.1728.v1","title":"Navigating the Complex Landscape of Fibrodysplasia Ossificans Progressiva: From Current Paradigms to Therapeutic Frontiers","year":2023,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Heterotopic Ossification and Related Conditions","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Muscular Dystrophy Canada; University of Alberta","funders":"Canadian Institutes of Health Research; Muscular Dystrophy Canada; Alberta Innovates; Alberta Innovates - Health Solutions; Women and Children's Health Research Institute; Children's Health Research Institute","keywords":"Fibrodysplasia ossificans progressiva; Clinical trial; Medicine; Engineering ethics; Heterotopic ossification; Bioinformatics; Biology; Pathology; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02126079,0.0006635237,0.001475637,0.001846993,0.001808211,0.008817841,0.001783682,0.004312783,0.004626418],"category_scores_gemma":[0.02268978,0.0003695939,0.0007711801,0.001023553,0.009474913,0.009625089,0.005778805,0.01009022,0.001515811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002234558,"about_ca_system_score_gemma":0.01066374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008677503,"about_ca_topic_score_gemma":0.001983166,"domain_scores_codex":[0.9927954,0.00378284,0.000558159,0.0006894871,0.001710643,0.0004634862],"domain_scores_gemma":[0.9728312,0.01922733,0.001603,0.001435556,0.003072649,0.001830273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000494766,0.0002361506,0.002785136,0.006562135,0.0001918124,0.001390256,0.00298682,0.001381765,0.0077688,0.2010153,0.08213326,0.6930537],"study_design_scores_gemma":[0.000122109,0.000651922,0.001518719,0.00742768,0.0001673179,0.003598548,0.003359808,0.0009410157,0.004176489,0.2680178,0.7098999,0.000118688],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005984138,0.5710242,0.02615091,0.3745587,0.007731749,0.0001120279,0.0002349823,0.0002180672,0.01398517],"genre_scores_gemma":[0.09175764,0.7349229,0.03995517,0.1007252,0.02540336,0.0005551998,0.0004236059,0.0002315023,0.006025542],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.02126079,"threshold_uncertainty_score":0.1124392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2329515782068645,"score_gpt":0.4242000220638067,"score_spread":0.1912484438569423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}