{"id":"W4387036061","doi":"10.20944/preprints202309.1728.v1","title":"Navigating the Complex Landscape of Fibrodysplasia Ossificans Progressiva: From Current Paradigms to Therapeutic Frontiers","year":2023,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Heterotopic Ossification and Related Conditions","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Muscular Dystrophy Canada; University of Alberta","funders":"Canadian Institutes of Health Research; Muscular Dystrophy Canada; Alberta Innovates; Alberta Innovates - Health Solutions; Women and Children's Health Research Institute; Children's Health Research Institute","keywords":"Fibrodysplasia ossificans progressiva; Clinical trial; Medicine; Engineering ethics; Heterotopic ossification; Bioinformatics; Biology; Pathology; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003919321,0.0003423481,0.0006414596,0.00009197785,0.0001799599,0.00003064738,0.0005907273,0.0003075615,0.000725645],"category_scores_gemma":[0.0001880956,0.0002455999,0.000319144,0.0003008912,0.0002154334,0.00002968889,0.0005500379,0.001906946,0.0008056014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008807355,"about_ca_system_score_gemma":0.0002711769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001379429,"about_ca_topic_score_gemma":0.000006632254,"domain_scores_codex":[0.9972626,0.0002005924,0.0008545032,0.000821388,0.0005082901,0.000352623],"domain_scores_gemma":[0.9972539,0.0001463985,0.0004729835,0.00170818,0.0001743746,0.0002441915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001186434,0.0003435731,0.9640222,0.0003791415,0.001060622,0.0000193734,0.006157447,0.0003694029,0.006185398,0.0002704752,0.001929613,0.01914416],"study_design_scores_gemma":[0.0006533786,0.00003622697,0.973319,0.001821767,0.000367044,0.000007832045,0.0007662983,0.001636646,0.003097719,0.001191735,0.01680574,0.0002966126],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9752164,0.0006305982,0.0009990254,0.01599613,0.001731322,0.003414966,0.0002474974,0.0003284268,0.001435601],"genre_scores_gemma":[0.9966795,0.0001805703,0.000433913,0.0002086942,0.0003333405,0.0009227355,0.0006670144,0.00005860906,0.0005156526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02146304,"threshold_uncertainty_score":0.9999996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2329515782068645,"score_gpt":0.4242000220638067,"score_spread":0.1912484438569423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}