{"id":"W4387041708","doi":"10.1021/acs.inorgchem.3c02714","title":"DFO-Km: A Modular Chelator as a New Chemical Tool for the Construction of Zirconium-89-Based Radiopharmaceuticals","year":2023,"lang":"en","type":"article","venue":"Inorganic Chemistry","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canada Foundation for Innovation","keywords":"Chemistry; Bifunctional; Chelation; Moiety; Linker; Combinatorial chemistry; Zirconium; Bioconjugation; Stereochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000211852,0.0002333625,0.0003658454,0.00002143993,0.0001039202,0.00002014564,0.0002694513,0.000261996,0.001080852],"category_scores_gemma":[0.0007742528,0.0001948409,0.0002547312,0.0005800404,0.0003315017,0.00003550939,0.00005130163,0.0003979876,0.00007481265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001104991,"about_ca_system_score_gemma":0.0006998786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004686561,"about_ca_topic_score_gemma":2.151543e-8,"domain_scores_codex":[0.9984149,0.000008865676,0.0004707339,0.0004101387,0.0003196644,0.0003756552],"domain_scores_gemma":[0.9983099,0.0004610695,0.0001276131,0.0005852675,0.0001309761,0.0003851623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002294609,0.00009445036,0.0001762636,0.0005332032,0.0001397263,0.000006841031,0.00003075698,0.0000209154,0.9931505,0.0001795866,0.003941701,0.001496647],"study_design_scores_gemma":[0.002682685,0.00001889238,0.00009251076,0.00006326415,0.0003842404,0.0001719866,0.00007105812,0.004628299,0.9668496,0.0004393897,0.02441004,0.0001880386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852244,0.000442835,0.001297148,0.01113774,0.00008828979,0.0007410072,0.00008881353,0.0002600469,0.0007197576],"genre_scores_gemma":[0.9956196,0.00007038103,0.001236805,0.0007268043,0.000687741,0.0001591044,0.0001347613,0.00004699233,0.001317841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02630085,"threshold_uncertainty_score":0.9998323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02836893572495406,"score_gpt":0.3323566941015196,"score_spread":0.3039877583765655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}