{"id":"W4387044427","doi":"10.1016/j.bas.2023.102101","title":"Intraoperative Raman Spectroscopy for real-time characterisation of IDH mutation and MGMT methylation status of adult Gliomas","year":2023,"lang":"en","type":"article","venue":"Brain and Spine","topic":"Brain Tumor Detection and Classification","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Methylation; Raman spectroscopy; DNA methylation; Cancer research; Medicine; Biology; Genetics; Gene; Physics; Optics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001823189,0.00008197552,0.0001682962,0.0001838069,0.00007569493,0.00002087878,0.00003019912,0.00004301316,0.0000118782],"category_scores_gemma":[0.0007323392,0.00007628914,0.00002639348,0.0003958998,0.00009249539,0.0001563412,0.0000117296,0.00003583354,0.000003332286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001462858,"about_ca_system_score_gemma":0.00002190801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001773549,"about_ca_topic_score_gemma":0.000006146158,"domain_scores_codex":[0.9992015,0.00008916404,0.0002596983,0.0002178707,0.0001038068,0.0001279064],"domain_scores_gemma":[0.9994202,0.0001878382,0.0001897232,0.00008544631,0.00007005312,0.00004671796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005328772,0.00001824931,0.00003423908,0.00009420924,0.000003383446,5.01218e-7,0.0008043956,0.00000229695,0.9641674,0.005517037,0.00002576998,0.02927925],"study_design_scores_gemma":[0.0007657195,0.0003657369,0.0417895,0.0000377138,0.00001284366,0.000006731561,0.0002415066,0.01626061,0.9390666,0.0009929431,0.0003677705,0.00009226872],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967383,0.0000645418,0.001845196,0.0005899112,0.00005059987,0.0004575409,0.00003432277,0.00005951964,0.0001600549],"genre_scores_gemma":[0.9964868,0.002580476,0.000585204,0.00006041771,0.00002971101,0.00004064734,0.00005113147,0.00001196665,0.0001536922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04175526,"threshold_uncertainty_score":0.3110981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02442190880438657,"score_gpt":0.3016266117013048,"score_spread":0.2772047028969182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}