{"id":"W4387047804","doi":"10.3390/curroncol30100633","title":"The New Era of Systemic Treatment for Hepatocellular Carcinoma: From the First Line to the Optimal Sequence","year":2023,"lang":"en","type":"review","venue":"Current Oncology","topic":"Hepatocellular Carcinoma Treatment and Prognosis","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Nivolumab; Sorafenib; Hepatocellular carcinoma; Ipilimumab; Ramucirumab; Bevacizumab; Oncology; Regorafenib; Internal medicine; Durvalumab; Pembrolizumab; Lenvatinib; Cancer; Immunotherapy; Colorectal cancer; Chemotherapy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006486921,0.0006837908,0.002313276,0.00007531715,0.0004363715,0.00004400898,0.0007824117,0.0003737996,0.00002602557],"category_scores_gemma":[0.0002467738,0.0002784864,0.001368867,0.0005104383,0.0001781856,0.00002133585,0.0002095949,0.0005671825,0.0002451653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001060642,"about_ca_system_score_gemma":0.00242857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005462983,"about_ca_topic_score_gemma":0.000303751,"domain_scores_codex":[0.9967977,0.0003971471,0.001168086,0.0006916017,0.0003300167,0.0006154832],"domain_scores_gemma":[0.9940103,0.003663207,0.0006159227,0.001282828,0.0001795299,0.0002481826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001362725,0.0002261128,0.004728791,0.003066609,0.001000914,0.00008375227,0.0008949497,0.000001522241,9.79482e-7,0.00009002634,0.01207424,0.9776958],"study_design_scores_gemma":[0.0012448,0.001822679,0.00003352701,0.007004031,0.00657916,0.0001008756,0.0001102355,0.0005516262,0.00001300776,0.00002091654,0.9822882,0.000230945],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002670146,0.9787261,0.0002069467,0.005679497,0.002022528,0.009928155,0.0006794261,0.00006396481,0.00002322966],"genre_scores_gemma":[0.004952291,0.9866812,0.0001079689,0.000067341,0.002238661,0.004284531,0.0009930907,0.0001084024,0.0005665169],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9774649,"threshold_uncertainty_score":0.9999667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4222211169854129,"score_gpt":0.4265163168720458,"score_spread":0.004295199886632906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}