{"id":"W4387048815","doi":"10.3390/ijms241914578","title":"Resveratrol and 3,3′-Diindolylmethane Differentially Regulate Aryl Hydrocarbon Receptor and Estrogen Receptor Alpha Activity through Multiple Transcriptomic Targets in MCF-7 Human Breast Cancer Cells","year":2023,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Direktør Throne Holsts Fond For Ernæringsforskning","keywords":"Aryl hydrocarbon receptor; Estrogen receptor alpha; Estrogen receptor; Chromatin immunoprecipitation; Biology; Transcriptome; Transcription factor; Estrogen receptor beta; Cancer research; Receptor; Resveratrol; Chromatin; Signal transduction; MCF-7; Chemistry; Cell biology; Molecular biology; Cancer cell; Gene; Gene expression; Promoter; Biochemistry; Breast cancer; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005974532,0.0002102787,0.0002729009,0.0002677316,0.0001305455,0.0001670096,0.0001137883,0.0001732254,0.001346453],"category_scores_gemma":[0.00005340921,0.0001308055,0.0004036289,0.0003386547,0.0001002332,0.00009912551,0.00008718773,0.0003045416,0.000458393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001892663,"about_ca_system_score_gemma":0.0001413662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00146609,"about_ca_topic_score_gemma":0.002541405,"domain_scores_codex":[0.9998671,0.0000112884,0.000008187643,0.00003695562,0.0000450068,0.00003138974],"domain_scores_gemma":[0.999972,0.00000542787,0.000006030704,0.000002869064,0.00000849864,0.000005229404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001261256,0.00001563054,0.0003142464,0.0000370311,0.000006924951,0.0000231626,0.00001501183,0.00003707715,0.9982613,0.00002521257,0.0000818784,0.001056471],"study_design_scores_gemma":[0.00002299482,0.0005117089,0.05804235,0.000009482341,0.00006435208,0.000253844,0.0001469544,0.0008758637,0.9336371,0.0000695307,0.006353904,0.00001190087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802169,0.007122359,0.0028211,0.0002891002,0.0001313425,0.00004900361,0.005555849,0.0001534914,0.003660774],"genre_scores_gemma":[0.9690011,0.004399057,0.003535847,0.0004276746,0.00003836727,0.0001425683,0.01210506,0.00003876027,0.01031146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00146609,"threshold_uncertainty_score":0.004504263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009305374676943484,"score_gpt":0.2726063100122386,"score_spread":0.2633009353352951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}