{"id":"W4387052604","doi":"10.1016/j.ebiom.2023.104804","title":"Distinct HLA associations with autoantibody-defined subgroups in idiopathic inflammatory myopathies","year":2023,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Inflammatory Myopathies and Dermatomyositis","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"European Social Fund; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Environmental Health Sciences; Vetenskapsrådet; Foundation for Research in Rheumatology; Department of Health and Social Care; Medical Research Council; Versus Arthritis; Stiftelsen Professor Nanna Svartz Fond; Reumatikerförbundet; Stiftelsen Börje Dahlins Fond; Ulla och Gustaf af Ugglas Stiftelse; European Commission; Stiftelsen Konung Gustaf V:s 80-årsfond; Norges Forskningsråd; Ministerstvo Školství, Mládeže a Tělovýchovy; European Science Foundation; Stockholms Läns Landsting; National Institute for Health and Care Research; Arthritis Research UK; Fonds de Recherche du Québec - Santé; Manchester Biomedical Research Centre; Torsten Söderbergs Stiftelse; Sixth Framework Programme; Hjärt-Lungfonden; Åke Wiberg Stiftelse","keywords":"Autoantibody; Human leukocyte antigen; Medicine; Immunology; Antibody; Antigen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001157474,0.0003647874,0.0008219586,0.0009651036,0.0002184069,0.00003390048,0.0001567188,0.0002223788,0.000125352],"category_scores_gemma":[0.0003877459,0.0002829457,0.0001125599,0.002104602,0.0003105876,0.0001795711,0.00009065825,0.0004727849,0.0004463999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002177054,"about_ca_system_score_gemma":0.0003080386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001004988,"about_ca_topic_score_gemma":0.0001797775,"domain_scores_codex":[0.9970717,0.0001135479,0.0008008764,0.0004706268,0.0008017864,0.0007415012],"domain_scores_gemma":[0.998592,0.0001694691,0.0002376599,0.0005378994,0.0001886272,0.0002743177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004309765,0.0001929005,0.9616275,0.000793845,0.0001380838,0.008536354,0.003161502,0.00001210972,0.009159706,0.003416205,0.01058134,0.001949463],"study_design_scores_gemma":[0.00444945,0.000515543,0.9832081,0.001111405,0.0001161635,0.0004284039,0.0007534314,0.0008397626,0.0004939912,0.0003112312,0.007415004,0.000357568],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879991,0.0004400626,0.00009674703,0.005348044,0.0005181606,0.0006843506,0.00004143811,0.0007986581,0.004073448],"genre_scores_gemma":[0.9969821,0.00008717131,0.0001411405,0.0006465879,0.0005860159,0.0001029341,0.0003394884,0.00007754797,0.001037026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02158053,"threshold_uncertainty_score":0.9999623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01142906590811612,"score_gpt":0.2553302414326825,"score_spread":0.2439011755245663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}