{"id":"W4387056103","doi":"10.1016/j.neurobiolaging.2023.09.010","title":"Early treatment with an M1 and sigma-1 receptor agonist prevents cognitive decline in a transgenic rat model displaying Alzheimer-like amyloid pathology","year":2023,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Agonist; Hippocampal formation; Hippocampus; Endocrinology; Internal medicine; Astrogliosis; Microglia; Medicine; Alzheimer's disease; Cognitive decline; Neurotrophic factors; Gliosis; Neuroscience; Receptor; Pharmacology; Psychology; Dementia; Disease; Central nervous system; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002826255,0.001067965,0.001481701,0.0007138484,0.0003782446,0.0005009887,0.000796769,0.001114827,0.002590321],"category_scores_gemma":[0.0003223842,0.0004296172,0.0006139401,0.0003068832,0.0006232897,0.0005717128,0.0002989424,0.002204877,0.0009811098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004861953,"about_ca_system_score_gemma":0.0009661038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00179523,"about_ca_topic_score_gemma":0.004416684,"domain_scores_codex":[0.9997092,0.00003406438,0.00002577907,0.00004368555,0.00004677755,0.0001404828],"domain_scores_gemma":[0.9993887,0.00005836012,0.0001374166,0.0000602669,0.00006607721,0.0002892008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008454571,0.001340053,0.0003104943,0.0001019163,0.00003551905,0.000193242,0.00006936766,0.00006515525,0.9844646,0.0001255748,0.0002872918,0.004552193],"study_design_scores_gemma":[0.0005348978,0.011952,0.005997794,0.00003656982,0.0001121679,0.0003617003,0.0001761894,0.0005812557,0.978331,0.0002086459,0.001670672,0.00003718764],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945347,0.001747415,0.001382789,0.0002566508,0.0001520345,0.00006362278,0.0005317902,0.0003198438,0.001011236],"genre_scores_gemma":[0.9868596,0.001839327,0.002378912,0.0002149249,0.00009491295,0.0001951935,0.0009416476,0.00006547797,0.007409875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002590321,"threshold_uncertainty_score":0.008665502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02533385130926385,"score_gpt":0.2953620172375458,"score_spread":0.2700281659282819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}