{"id":"W4387056103","doi":"10.1016/j.neurobiolaging.2023.09.010","title":"Early treatment with an M1 and sigma-1 receptor agonist prevents cognitive decline in a transgenic rat model displaying Alzheimer-like amyloid pathology","year":2023,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Agonist; Hippocampal formation; Hippocampus; Endocrinology; Internal medicine; Astrogliosis; Microglia; Medicine; Alzheimer's disease; Cognitive decline; Neurotrophic factors; Gliosis; Neuroscience; Receptor; Pharmacology; Psychology; Dementia; Disease; Central nervous system; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001831529,0.0002270058,0.0003018596,0.00008191601,0.00007862974,0.000008608842,0.0001169837,0.0001693559,0.000008384438],"category_scores_gemma":[0.00001387671,0.0001788278,0.00005876217,0.0001265956,0.0001718458,0.000009303641,0.00008996073,0.0001215878,0.000002967555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008937973,"about_ca_system_score_gemma":0.00004424724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001784898,"about_ca_topic_score_gemma":0.00004797443,"domain_scores_codex":[0.9985719,0.0002340948,0.0002146649,0.000554381,0.0000524958,0.0003724507],"domain_scores_gemma":[0.9995812,0.00007099014,0.0000867994,0.0001325511,0.00002881415,0.00009969361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006389752,0.0001481525,0.005996341,0.00001251691,0.00006854437,0.00002031504,0.0002020646,0.0004237749,0.9887532,0.000006761972,0.000009251693,0.003720091],"study_design_scores_gemma":[0.004468265,0.009268259,0.01025324,0.00005941442,0.0001644574,0.00003173831,0.0001109481,0.001834134,0.9731719,0.00009874577,0.0001422141,0.0003966496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987465,0.0002169126,0.0003445084,0.00009938793,0.0001188102,0.0003785443,0.00004848936,0.00002600178,0.00002084333],"genre_scores_gemma":[0.998134,0.0007382873,0.0003783022,0.0003354904,0.00003811634,0.00008529464,0.0002211513,0.00002617874,0.00004315891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01558127,"threshold_uncertainty_score":0.7292388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02533385130926385,"score_gpt":0.2953620172375458,"score_spread":0.2700281659282819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}