{"id":"W4387062081","doi":"10.1016/j.lfs.2023.122102","title":"EPO prevents neuroinflammation and relieves depression via JAK/STAT signaling","year":2023,"lang":"en","type":"article","venue":"Life Sciences","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Science, Technology and Innovation Commission of Shenzhen Municipality; Guangdong Medical Research Foundation","keywords":"Erythropoietin; Neuroinflammation; Ruxolitinib; Pharmacology; Cytokine; Medicine; Behavioural despair test; Tail suspension test; Antidepressant; Inflammation; Immunology; Endocrinology; Hippocampus; Myelofibrosis; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007276859,0.0002184736,0.0002275717,0.0001298108,0.0001196267,0.0001836422,0.000148326,0.0002257028,0.002430362],"category_scores_gemma":[0.00009389244,0.00007706383,0.0002178703,0.00004974157,0.0002305155,0.0001506866,0.0001415298,0.000939182,0.0003175391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001155725,"about_ca_system_score_gemma":0.0002534674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000358411,"about_ca_topic_score_gemma":0.001070585,"domain_scores_codex":[0.9999573,0.000007330141,0.000003993771,0.000005838316,0.0000105961,0.00001489251],"domain_scores_gemma":[0.999969,0.000003240069,0.000006748306,0.000003092662,0.000003614344,0.00001426271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009740284,0.002074759,0.0009968191,0.0003270327,0.0001478146,0.0004189653,0.00005355815,0.0004235063,0.930589,0.001079588,0.002603172,0.05154559],"study_design_scores_gemma":[0.005119893,0.00933854,0.03322434,0.0001261013,0.0003811276,0.001151954,0.0002307143,0.003417207,0.9209043,0.001928627,0.02412894,0.00004816207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904089,0.00260582,0.001644317,0.0005278113,0.0002026016,0.00006212655,0.0005271544,0.0001894817,0.00383186],"genre_scores_gemma":[0.9910681,0.001694891,0.001161294,0.0001828963,0.00007183419,0.00005403729,0.0004241652,0.00001930992,0.005323527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002430362,"threshold_uncertainty_score":0.008130312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03949660195593874,"score_gpt":0.2878116476827611,"score_spread":0.2483150457268223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}