{"id":"W4387077144","doi":"10.1002/adma.202304654","title":"Brain‐Targeted Liposomes Loaded with Monoclonal Antibodies Reduce Alpha‐Synuclein Aggregation and Improve Behavioral Symptoms in Parkinson's Disease","year":2023,"lang":"en","type":"article","venue":"Advanced Materials","topic":"Neurological disorders and treatments","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Ben-Gurion University of the Negev; European Commission; Tel Aviv University; Rothschild Caesarea Foundation; Michael J. Fox Foundation for Parkinson's Research; Phospholipid Research Center; Hebrew University of Jerusalem; Israel National Institute for Health Policy Research; Azrieli Foundation; Israel Science Foundation; Jewish National Fund; Teva Pharmaceutical Industries","keywords":"Neuroinflammation; Blood–brain barrier; Monoclonal antibody; Neurodegeneration; Transferrin; Liposome; Pharmacology; Parkinson's disease; In vivo; Transferrin receptor; Neuroscience; Medicine; Chemistry; Antibody; Biology; Immunology; Disease; Biochemistry; Pathology; Central nervous system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007666947,0.0003133791,0.0002624199,0.0001820747,0.00007661708,0.0001249235,0.0001110272,0.0002889649,0.0006403878],"category_scores_gemma":[0.00005568511,0.0000943985,0.0001643151,0.00006843873,0.0001121696,0.0002207896,0.0001530039,0.0002876066,0.0001465816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001629114,"about_ca_system_score_gemma":0.000130728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003401027,"about_ca_topic_score_gemma":0.000412746,"domain_scores_codex":[0.9999714,0.000004819171,0.000003105947,0.000005874859,0.000005931499,0.000008827942],"domain_scores_gemma":[0.9999837,0.000001785264,0.000005239458,9.970362e-7,0.000003212397,0.000005100968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005305908,0.0001414346,0.0001380103,0.00008176374,0.00001622323,0.00004215903,0.00001362225,0.0001304976,0.9920191,0.00007516678,0.0001112108,0.006700083],"study_design_scores_gemma":[0.0002397811,0.002349945,0.004230574,0.00001452126,0.0000881891,0.0001996233,0.00002153883,0.001771565,0.9887531,0.0001273584,0.002194947,0.000008873327],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993564,0.003587404,0.001888801,0.0001085698,0.00004171425,0.00003336506,0.00007295611,0.00009366035,0.0006096709],"genre_scores_gemma":[0.9955806,0.001811875,0.001178381,0.00005584008,0.000009520732,0.00003236933,0.0001163135,0.000009948822,0.001205101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006403878,"threshold_uncertainty_score":0.00214231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0148722467993087,"score_gpt":0.2880474798454218,"score_spread":0.2731752330461131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}