{"id":"W4387077428","doi":"10.1128/iai.00201-23","title":"<i>Mycobacterium tuberculosis</i> infection drives differential responses in the bone marrow hematopoietic stem and progenitor cells","year":2023,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Christie (Canada)","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; European Social Fund; National Heart, Lung, and Blood Institute; Georgia Clinical and Translational Science Alliance; Agencia Estatal de Investigación; National Cancer Institute; National Institutes of Health; Ministerio de Ciencia e Innovación; National Center for Research Resources; Alvin J. Siteman Cancer Center","keywords":"Biology; Haematopoiesis; Lymphopoiesis; Progenitor cell; Immunology; Stem cell; Mycobacterium tuberculosis; Bone marrow; Immune system; Myeloid; Hematopoietic stem cell; Cell biology; Tuberculosis; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005070284,0.0001627009,0.0001968369,0.0002844078,0.0005621887,0.00007744948,0.00005765671,0.0001816874,0.00007745213],"category_scores_gemma":[0.00006119486,0.0001240988,0.00006746427,0.0003218364,0.000127861,0.0001604844,0.0001074916,0.0003875221,0.0000888713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002473652,"about_ca_system_score_gemma":0.00002482575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007166895,"about_ca_topic_score_gemma":0.0001775245,"domain_scores_codex":[0.9982412,0.001040495,0.0002565492,0.0001805566,0.00003680456,0.0002443824],"domain_scores_gemma":[0.9992671,0.0003681826,0.00007783453,0.0002259657,0.00004487411,0.00001606526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004422249,0.0002843021,0.08161147,0.0001103763,0.0000974116,0.000004780512,0.003665425,0.000001682697,0.9034304,0.0003117873,0.0008956777,0.009144453],"study_design_scores_gemma":[0.001119795,0.0002297255,0.9253324,0.00004328571,0.00005038881,0.0002747548,0.0006207683,0.00001514863,0.05749312,0.00008003759,0.01456012,0.0001804492],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975825,0.0006602191,0.00002322363,0.0003893124,0.0007603554,0.000342826,0.00001574648,0.0001211767,0.0001046166],"genre_scores_gemma":[0.9966309,0.002062336,0.000001455383,0.00005379063,0.0000257458,0.00008119467,0.00004458299,0.00001203096,0.001087934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8459373,"threshold_uncertainty_score":0.5060604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01404464059443008,"score_gpt":0.2516701574290983,"score_spread":0.2376255168346682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}