{"id":"W4387077428","doi":"10.1128/iai.00201-23","title":"<i>Mycobacterium tuberculosis</i> infection drives differential responses in the bone marrow hematopoietic stem and progenitor cells","year":2023,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Christie (Canada)","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; European Social Fund; National Heart, Lung, and Blood Institute; Georgia Clinical and Translational Science Alliance; Agencia Estatal de Investigación; National Cancer Institute; National Institutes of Health; Ministerio de Ciencia e Innovación; National Center for Research Resources; Alvin J. Siteman Cancer Center","keywords":"Biology; Haematopoiesis; Lymphopoiesis; Progenitor cell; Immunology; Stem cell; Mycobacterium tuberculosis; Bone marrow; Immune system; Myeloid; Hematopoietic stem cell; Cell biology; Tuberculosis; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001802358,0.0002022218,0.0002092864,0.000191449,0.0000997988,0.0004064536,0.0001146502,0.0002422248,0.000935623],"category_scores_gemma":[0.000101477,0.0001331988,0.0001277151,0.0001212392,0.000263291,0.0001537271,0.0002525289,0.0005848196,0.0004059391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000174435,"about_ca_system_score_gemma":0.0001165707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001901334,"about_ca_topic_score_gemma":0.0003594019,"domain_scores_codex":[0.9997892,0.00003566796,0.00002654523,0.00004506307,0.00004591174,0.00005769705],"domain_scores_gemma":[0.9998399,0.00003523746,0.00005064062,0.00002053629,0.0000129735,0.00004061962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003526319,0.00001073809,0.0002411712,0.000008310966,8.169848e-7,0.00001521575,0.000005932158,0.000008195057,0.9993865,0.00003067625,0.00001196035,0.0002450827],"study_design_scores_gemma":[0.00001210561,0.0004702972,0.02316406,0.000009718566,0.00000876857,0.0003284923,0.00008533254,0.0004662703,0.9742589,0.00005727672,0.001135467,0.000003290416],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972364,0.0005716744,0.0008051168,0.00005217647,0.000008329196,0.0000156496,0.0003554639,0.00004449783,0.0009106475],"genre_scores_gemma":[0.9976693,0.000269811,0.0006570292,0.00007013509,0.0000076075,0.00002189888,0.0004200812,0.00001692322,0.0008671302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000935623,"threshold_uncertainty_score":0.003129959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01404464059443008,"score_gpt":0.2516701574290983,"score_spread":0.2376255168346682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}